In-silico identification of novel Cis-aconitate decarboxylase inhibitors as potential anti-inflammatory agents using molecular docking and dynamics
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-26473-4
Abstract: Cis-aconitate decarboxylase (CAD), also known as ACOD1 or IRG1, catalyzes the conversion of cis-aconitate to itaconate, playing a pivotal role in innate immunity and inflammatory diseases. Although CAD is a key enzyme in the pathophysiology… read more here.
Keywords: aconitate decarboxylase; cad; inflammatory; cis aconitate ... See more keywords
Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo2028
Abstract: Sepsis is a challenging clinical syndrome caused by a dysregulated host response to infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 (ACOD1) in monocytes and macrophages. Previous studies have suggested that… read more here.
Keywords: sepsis; cdk2; aconitate decarboxylase; polymicrobial sepsis ... See more keywords
Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084392
Abstract: Ulcerative colitis is a complex inflammatory bowel disorder disease that can induce rectal and colonic dysfunction. Although the prevalence of IBD in Western countries is almost 0.5% of the general population, genetic causes are still… read more here.
Keywords: induced colitis; aconitate decarboxylase; itaconate; dss induced ... See more keywords