Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells.
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DOI: 10.1016/j.toxlet.2021.04.020
Abstract: Aconitine, a highly toxic alkaloid derived from Aconitum L., affects the central nervous system and peripheral nervous system. However, the underlying mechanism of aconitine-induced neurotoxicity remains unclear. This study investigates the effects and mechanism of… read more here.
Keywords: energy metabolism; aconitine induces; sy5y cells; mitochondrial energy ... See more keywords