A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients
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DOI: 10.1038/s41598-020-76842-4
Abstract: This study aimed to evaluate the effectiveness of abatacept (ABA) by anti-cyclic citrullinated peptide (ACPA) status on disease activity as well as radiographic progression in patients with rheumatoid arthritis (RA) in clinical settings. A retrospective… read more here.
Keywords: citrullinated peptide; anti cyclic; effectiveness abatacept; acpa positive ... See more keywords
The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in clinically suspect arthralgia
Sign Up to like & getrecommendations! Published in 2017 at "Rheumatology"
DOI: 10.1093/rheumatology/kex340
Abstract: Objectives Autoantibody testing is helpful for predicting the risk of progression to clinical arthritis in subjects at risk. Previous longitudinal studies have mainly selected autoantibody-positive arthralgia patients, and consequently the predictive values of autoantibodies were… read more here.
Keywords: autoantibody; risk; acpa positive; development ... See more keywords
Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-209991
Abstract: Objectives To determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the general population. Methods Lifelines is a multidisciplinary prospective population-based cohort study in the… read more here.
Keywords: based cohort; population based; protein antibodies; acpa positive ... See more keywords
Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-211620
Abstract: Objectives To study whether oral contraceptive (OC) use or breastfeeding (BF) influence the risk of rheumatoid arthritis (RA), stratifying the cases by presence/absence of anticitrullinated protein antibodies (ACPA), and whether these factors interact with known… read more here.
Keywords: decreased risk; risk; use; risk acpa ... See more keywords
Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-212404
Abstract: Objectives Bone loss is a well-established consequence of rheumatoid arthritis (RA). To date, bone disease in RA is exclusively characterised by bone density measurements, while the functional properties of bone in RA are undefined. This… read more here.
Keywords: failure load; properties bone; bone; rheumatoid arthritis ... See more keywords
SAT0060 Response to conventional synthetic dmards differs depending on rheumatoid factor levels in anti-citrullinated positive patients with early rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.5778
Abstract: Background In rheumatoid arthritis (RA), several autoantibody characteristics, including specifities, levels and isotypes, may influence their pathogenic properties and impact on clinical presentation and outcomes of the disease (1, 2). In particular, classical IgM rheumatoid… read more here.
Keywords: acpa positive; response; positive patients; disease ... See more keywords
Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Epigenetics"
DOI: 10.1186/s13148-019-0699-9
Abstract: ObjectiveTo compare DNA methylation in subjects positive vs negative for anti-citrullinated protein antibodies (ACPA), a key serological marker of rheumatoid arthritis (RA) risk.MethodsWith banked serum from a random subset (N = 3600) of a large general population… read more here.
Keywords: dna methylation; relevant dna; rheumatoid arthritis; acpa positive ... See more keywords
The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of managed care & specialty pharmacy"
DOI: 10.18553/jmcp.2017.17129
Abstract: BACKGROUND Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA diagnosis and prognosis.… read more here.
Keywords: diagnosis; positive status; economic burden; acpa positive ... See more keywords
Serum Antigenome Profiling Reveals Diagnostic Models for Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.884462
Abstract: Objective The study aimed to investigate the serum antigenomic profiling in rheumatoid arthritis (RA) and determine potential diagnostic biomarkers using label-free proteomic technology implemented with machine-learning algorithm. Method Serum antigens were captured from a cohort… read more here.
Keywords: positive acpa; acpa negative; serum; rheumatoid arthritis ... See more keywords
How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.930112
Abstract: The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE). RA is preceded by… read more here.
Keywords: citrullinated peptides; carrier; hla; hapten carrier ... See more keywords
The Infectious Basis of ACPA-Positive Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.01853
Abstract: Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers… read more here.
Keywords: basis acpa; rheumatoid; rheumatoid arthritis; acpa positive ... See more keywords