Evidence for Increased Response to Induced Endoplasmic Reticulum Stress in Myeloid Cells in Acquired Aplastic Anemia
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DOI: 10.1097/mph.0000000000000810
Abstract: Autoimmune response targeting the hematopoietic stem cells highlights the current understanding of acquired aplastic anemia (AAA) pathogenesis. Upregulation of the unfolded protein response is the cell’s rejoinder to a variety of stresses, which either result… read more here.
Keywords: aplastic anemia; response; myeloid cells; acquired aplastic ... See more keywords
Molecular pathogenesis of acquired aplastic anemia
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DOI: 10.1111/ejh.13182
Abstract: The application of next‐generation sequencing (NGS) has enhanced our understanding of the genetic landscape in acquired aplastic anemia (AA). Parallel progress has been in addressing aspects underlying immune dysregulation in disease pathogenesis. Novel insights into… read more here.
Keywords: pathogenesis acquired; acquired aplastic; aplastic anemia; molecular pathogenesis ... See more keywords
Immunosuppressive therapy (IST) in adult patients with acquired aplastic anemia (AA): A single‐center experience over the past 15 years
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DOI: 10.1111/ejh.13235
Abstract: Immunosuppressive therapy (IST) with horse anti‐thymocyte globulin (hATG) and cyclosporine (CsA) is considered one of the first‐line therapies in patients (pts) with acquired aplastic anemia (AA). read more here.
Keywords: aplastic anemia; immunosuppressive therapy; therapy ist; acquired aplastic ... See more keywords
Efficacy and safety of porcine ALG compared to rabbit ATG as first‐line treatment for children with acquired aplastic anemia
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DOI: 10.1111/ejh.13398
Abstract: To assess the outcomes of children with acquired aplastic anemia (AA) treated in China with first‐line porcine anti‐lymphocyte immunoglobulin (p‐ALG)/rabbit anti‐thymocyte immunoglobulin (r‐ATG) combined with cyclosporine A (CSA). read more here.
Keywords: first line; aplastic anemia; acquired aplastic; children acquired ... See more keywords
Acquired aplastic anemia following SARS‐CoV‐2 vaccination
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DOI: 10.1111/ejh.13788
Abstract: COVID‐19 is a potential life‐threatening viral disease caused by SARS‐CoV‐2 and was declared a pandemic by the WHO in March 2020. mRNA‐based SARS‐CoV‐2 vaccines are routinely recommended in immune‐compromised patients, including patients with AA, as… read more here.
Keywords: acquired aplastic; vaccination; relapse; cov vaccination ... See more keywords
Revisiting acquired aplastic anaemia: current concepts in diagnosis and management
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DOI: 10.1111/imj.14140
Abstract: Acquired aplastic anaemia is a rare, serious, immunologically mediated bone marrow failure syndrome, characterised by marrow hypoplasia of varying severity and significant pancytopenia. Careful attention and investigation, including molecular testing, is required to confirm the… read more here.
Keywords: revisiting acquired; diagnosis; acquired aplastic; management ... See more keywords
Hodgkin lymphoma patients have an increased incidence of idiopathic acquired aplastic anemia
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DOI: 10.1371/journal.pone.0215021
Abstract: Idiopathic acquired aplastic anemia (AA) is a rare lymphocyte-mediated bone marrow aplasia. No specific mechanisms or triggers of AA have been identified. We recently observed several patients who developed AA after Hodgkin lymphoma (HL). We… read more here.
Keywords: incidence; aplastic anemia; hodgkin lymphoma; diagnosis ... See more keywords
Impaired immunosuppressive role of myeloid-derived suppressor cells in acquired aplastic anemia
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DOI: 10.3324/haematol.2021.280292
Abstract: Myeloid-derived suppressor cells (MDSC) are a group of heterogeneous immature myeloid cells and display immunosuppressive function. In this study, MDSC populations were evaluated in acquired aplastic anemia (AA) (n=65) in which aberrant immune mechanisms contributed… read more here.
Keywords: myeloid derived; acquired aplastic; suppressor cells; myeloid ... See more keywords
Comparison of Hematopoietic Stem Cell Transplantation Outcomes Using Matched Sibling Donors, Haploidentical Donors, and Immunosuppressive Therapy for Patients With Acquired Aplastic Anemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.837335
Abstract: We retrospectively compared the outcomes of 387 consecutive patients with acquired aplastic anemia (AA) who underwent hematopoietic stem cell transplantation (HSCT) with a fludarabine-based conditioning regimen from matched sibling donors (MSD) (n = 108) or… read more here.
Keywords: patients acquired; hsct; hid hsct; acquired aplastic ... See more keywords
Population Pharmacokinetics of Cyclosporine in Chinese Pediatric Patients With Acquired Aplastic Anemia
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DOI: 10.3389/fphar.2022.933739
Abstract: Cyclosporine (CsA) is a component of the first-line treatment for acquired aplastic anemia (acquired AA) in pediatric patients. This study aimed to develop a population pharmacokinetic (PK) model of CsA in Chinese pediatric patients with… read more here.
Keywords: patients acquired; acquired aplastic; model; pediatric patients ... See more keywords
Anti-Thymocyte Globulin (ATG)-Free Nonmyeloablative Haploidentical PBSCT Plus Post-Transplantation Cyclophosphamide Is a Safe and Efficient Treatment Approach for Pediatric Acquired Aplastic Anemia
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DOI: 10.3390/ijms232315192
Abstract: Most cases of acquired aplastic anemia (AA) arise from autoimmune destruction of hematopoietic stem and progenitor cells. Human leukocyte antigen (HLA)-haploidentical nonmyeloablative hematopoietic stem cell transplantation (HSCT) plus post-transplantation cyclophosphamide (PTCy) is increasingly applied to… read more here.
Keywords: post transplantation; acquired aplastic; plus post; transplantation cyclophosphamide ... See more keywords