Tumor cell-intrinsic phenotypic plasticity facilitates adaptive cellular reprogramming driving acquired drug resistance
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-017-0435-1
Abstract: The enthusiasm about successful novel therapeutic strategies in cancer is often quickly dampened by the development of drug resistance. This is true for targeted therapies using tyrosine kinase inhibitors for EGFR or BRAF mutant cancers,… read more here.
Keywords: drug resistance; intrinsic phenotypic; drug; resistance ... See more keywords
Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response
Sign Up to like & getrecommendations! Published in 2017 at "Translational Oncology"
DOI: 10.1016/j.tranon.2016.11.008
Abstract: Epithelial-to-mesenchymal transition (EMT) is linked to tumor invasion, drug resistance and aggressive disease and this is largely dependent on the cell's microenvironment. Acriflavine (ACF) is an old antibacterial drug recently also suggested as anticancer agent… read more here.
Keywords: drug resistance; mesenchymal transition; drug; epithelial mesenchymal ... See more keywords
Abstract 4027: TSN084, a multi-kinase inhibitor, overcomes acquired drug-resistant mutations of cMet, Trks, and Flt3, and displays broad activities against kinase oncotargets Axl, DDRs, and CDK8/19
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4027
Abstract: Background: Up to date, over 80 small molecule kinase inhibitors have been approved for the treatment of cancers worldwide. This class of targeted therapy benefits millions of patients by improving their disease management and quality… read more here.
Keywords: tsn084; acquired drug; drug resistant; multi kinase ... See more keywords
Genetic Diversity and Acquired Drug Resistance Mutations Detected by Deep Sequencing in Virologic Failures Among Antiretroviral Treatment Experienced Human Immunodeficiency Virus-1 Patients in a Pastoralist Region of Ethiopia [Corrigendum]
Sign Up to like & getrecommendations! Published in 2021 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s352888
Abstract: [This corrects the article DOI: 10.2147/IDR.S337485.]. read more here.
Keywords: drug; drug resistance; diversity acquired; genetic diversity ... See more keywords