Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32256
Abstract: Sunitinib is one of the most widely used targeted therapeutics for renal cell carcinoma (RCC), but acquired resistance against targeted therapies remains a major clinical challenge. To dissect mechanisms of acquired resistance and unravel reliable… read more here.
Keywords: renal cell; resistance; acquired resistance; resistance sunitinib ... See more keywords
Immune Therapy: What Can We Learn From Acquired Resistance?
Sign Up to like & getrecommendations! Published in 2021 at "Lung Cancer"
DOI: 10.1007/978-3-030-74028-3_5
Abstract: Programmed death-1 (PD-1) pathway inhibitors have revolutionized the treatment of locally advanced and advanced non-small cell lung cancer (NSCLC). Response to these agents can be durable, but most patients will go on to develop resistance… read more here.
Keywords: immune therapy; therapy learn; resistance; acquired resistance ... See more keywords
Acquired resistance to cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-018-0692-y
Abstract: In recent times, advances in cancer immunotherapy have yielded impressive, durable clinical responses in patients with varied subtypes of cancer. However, a significant proportion of patients who initially demonstrate encouraging tumor regression develop resistance and… read more here.
Keywords: acquired resistance; resistance; cancer immunotherapy; resistance cancer ... See more keywords
Control efficacy of the systemic acquired resistance (SAR) inducer acibenzolar-S-methyl against Venturia nashicola in Japanese pear orchards
Sign Up to like & getrecommendations! Published in 2021 at "Journal of General Plant Pathology"
DOI: 10.1007/s10327-021-01013-w
Abstract: Scab caused by Venturia nashicola is one of the most serious diseases of Asian pears, and conventional fungicides used to control scab can lose their efficacy when fungicide-resistant strains develop. In contrast, the efficacy of… read more here.
Keywords: venturia nashicola; efficacy; resistance sar; efficacy systemic ... See more keywords
Strategies to overcome acquired resistance to EGFR TKI in the treatment of non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-019-02075-1
Abstract: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) represents a paradigm shift in the treatment of non-small cell lung cancer (NSCLC) patients and has been the first-line therapy in clinical practice. While erlotinib, gefitinib… read more here.
Keywords: egfr; treatment; egfr tki; acquired resistance ... See more keywords
Acquired Resistance to Drugs Targeting Tyrosine Kinases
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2018.02.003
Abstract: Abstract Resistance to chemotherapeutic drugs exemplifies the greatest hindrance to effective treatment of cancer patients. The molecular mechanisms responsible have been investigated for over 50 years and have revealed the lack of a single cause,… read more here.
Keywords: targeting tyrosine; tyrosine; acquired resistance; resistance ... See more keywords
Nanoparticles for co-delivery of Osimertinib and Selumetinib to Overcome Osimertinib-acquired Resistance in Non-small Cell Lung Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.05.018
Abstract: Osimertinib (OSI) is the first FDA-approved third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It can be used for treating non-small cell lung cancer (NSCLC) patients with activating EGFR mutation and for patients… read more here.
Keywords: nsclc; acquired resistance; resistance; osimertinib ... See more keywords
Vorinostat combined with brigatinib overcomes acquired resistance in EGFR-C797S-mutated lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.03.022
Abstract: The development of a new generation of tyrosine kinase inhibitors (TKIs) has improved the treatment response in lung adenocarcinomas. However, acquired resistance often occurs due to new epidermal growth factor receptor (EGFR) mutations. In particular,… read more here.
Keywords: egfr; c797s; vorinostat; acquired resistance ... See more keywords
Acquired resistance to a nucleopolyhedrovirus in the smaller tea tortrix Adoxophyes honmai (Lepidoptera: Tortricidae) after selection by serial viral administration.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of invertebrate pathology"
DOI: 10.1016/j.jip.2017.03.003
Abstract: A laboratory colony of Adoxophyes honmai was selected for resistance over 156 generations by feeding neonate larvae of every generation with the LC60 or LC70 of its nucleopolyhedrovirus, Adoxophyes honmai nucleopolyhedrovirus (AdhoNPV). A significant difference… read more here.
Keywords: lc50 values; adoxophyes honmai; selection; acquired resistance ... See more keywords
Next-generation sequencing reveals novel resistance mechanisms and molecular heterogeneity in EGFR-mutant non-small cell lung cancer with acquired resistance to EGFR-TKIs.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2017.09.005
Abstract: OBJECTIVES Despite initial responses to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in EGFR mutant non-small cell lung cancer, patients invariably develop acquired resistance. In this study, we performed next-generation sequencing in pre- and… read more here.
Keywords: egfr; egfr tkis; acquired resistance; resistance ... See more keywords
A combinatorial strategy for overcoming primary and acquired resistance of MEK inhibition in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112060
Abstract: Compared with traditional chemotherapeutic drugs, targeted therapeutic medicine has the advantages of high efficacy and less toxic side effects. However, in clinical practice for treatment of colorectal cancer, the primary and acquired resistance of these… read more here.
Keywords: medicine; colorectal cancer; acquired resistance; primary acquired ... See more keywords