Effect of selumetinib plus AZD8186 treatment on cabazitaxel sensitivity in docetaxel-acquired resistant metastatic prostate cancer cell lines
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DOI: 10.1093/annonc/mdz268.077
Abstract: Abstract Background PI3K/AKT/mTOR and MEK/ERK signalling pathways act cooperatively to develop taxane resistance in metastatic castration resistant prostate cancer (mCRPC). Inhibition of one of the pathways promotes a negative feedback that activates the other one.… read more here.
Keywords: akt; pc3; treatment; effect ... See more keywords