Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.01.010
Abstract: The overexpression of multidrug efflux pumps is an important mechanism of clinical resistance in Gram-negative bacteria. Recently, four small molecules were discovered that inhibit efflux in Escherichia coli and interact with the AcrAB-TolC efflux pump… read more here.
Keywords: component acra; binding sites; acrab tolc; efflux pump ... See more keywords
Resveratrol controls Escherichia coli growth by inhibiting the AcrAB‐TolC efflux pump
Sign Up to like & getrecommendations! Published in 2019 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fnz030
Abstract: &NA; Resveratrol (RSV), a phytoalexin found in grapes and other plants, is known to have antibacterial effects against Escherichia coli. In this study, we aimed to identify the target gene(s) for the antibacterial activity of… read more here.
Keywords: pump; rsv; tolc; acrab tolc ... See more keywords
Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity
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DOI: 10.1126/science.aaf4762
Abstract: Drug efflux machinery inherited asymmetrically In dividing bacterial cells, asymmetric distribution of cell wall constituents occurs between mother cells and their progeny. Asymmetric distribution of efflux machinery in a growing population of bacterial cells results… read more here.
Keywords: multidrug efflux; acrab tolc; long lived; efflux pump ... See more keywords
Role of AcrAB-TolC multidrug efflux pump in drug-resistance acquisition by plasmid transfer
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DOI: 10.1126/science.aav6390
Abstract: A race against time Clinically relevant antimicrobial resistance is largely spread via plasmids that disperse among bacteria during conjugation. How quickly can a resistance gene be expressed after transfer? In susceptible bacterial cells, tetracycline should… read more here.
Keywords: efflux pump; resistance acquisition; resistance; acrab tolc ... See more keywords
A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump
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DOI: 10.3390/antibiotics11010052
Abstract: RND family efflux pumps are complex macromolecular machines involved in multidrug resistance by extruding antibiotics from the cell. While structural studies and molecular dynamics simulations have provided insights into the architecture and conformational states of… read more here.
Keywords: state; tripartite efflux; transport; pump ... See more keywords