Promoter screening and identification for metabolic regulation in Acremonium chrysogenum
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DOI: 10.1002/biot.202300683
Abstract: Acremonium chrysogenum is the major industrial producer of cephalosporin C (CPC), which is used as raw material for the production of significant cephalosporin antibiotics. Due to the lack of diverse promoter elements, the development of… read more here.
Keywords: acremonium chrysogenum; promoter screening; promoter; chrysogenum ... See more keywords
The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum
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DOI: 10.1038/s41597-025-05645-x
Abstract: Acremonium chrysogenum is a notable filamentous fungus recognized for its essential contribution to the pharmaceutical sector through the biosynthesis of cephalosporin C (CPC). CPC functions as a key intermediate in the biosynthesis of β-lactam antibiotics,… read more here.
Keywords: acremonium chrysogenum; telomere telomere; chrysogenum; chromosome scale ... See more keywords
Effect of catalase on CPC production during fermentation of Acremonium chrysogenum
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DOI: 10.1186/s40643-024-00831-y
Abstract: Cephalosporin C (CPC) is a critical raw material for cephalosporin antibiotics produced by Acremonium chrysogenum. During fermentation, the oxygen supply is a crucial factor limiting the efficient biosynthesis of CPC. This study demonstrated that the… read more here.
Keywords: acremonium chrysogenum; chrysogenum; fermentation; catalase cpc ... See more keywords
Spermidine and 1,3-Diaminopropane Have Opposite Effects on the Final Stage of Cephalosporin C Biosynthesis in High-Yielding Acremonium chrysogenum Strain
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DOI: 10.3390/ijms232314625
Abstract: The addition of exogenous polyamines increases the production of antibiotic cephalosporin C (CPC) in Acremonium chrysogenum high-yielding (HY) strain during fermentation on a complex medium. However, the molecular basis of this phenomenon is still unknown.… read more here.
Keywords: addition; high yielding; spermidine diaminopropane; acremonium chrysogenum ... See more keywords
Comparative Proteomic Analysis of Acremonium chrysogenum Strains: Key Changes Converting the Wild-Type Strain into Antibiotic Cephalosporin C Biofactory
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DOI: 10.3390/jof11110822
Abstract: Acremonium chrysogenum is the only industrial producer of the antibiotic cephalosporin C (CPC), the starting substance for manufacturing cephalosporins of the first to fifth generations. Strains produced for industrial use are significantly improved by multiple… read more here.
Keywords: acremonium chrysogenum; antibiotic cephalosporin; chrysogenum; key changes ... See more keywords