Biological perspective of a triazine derivative with isatin/chalcone/acridone: DFT and docking investigations
Sign Up to like & getrecommendations! Published in 2020 at "Structural Chemistry"
DOI: 10.1007/s11224-020-01609-6
Abstract: The article highlights insights into biological activity using computational methods in products of 1,3,5-triazine-2,4-diamine with 1H-indole-2,3-dione (isatin)/(2E)-13-diphenylprop-2-en-1-one (chalcone)/10H-acridin-9-one (acridone). Biological activity is carried out using the method of electron density, 6-311++G(d,p) for molecular and electronic… read more here.
Keywords: biological activity; isatin; biological perspective; acridone ... See more keywords
Structural optimizations and bioevaluation of N-substituted acridone derivatives as strong topoisomerase II inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105543
Abstract: Previously, an array of N-substituted acridone derivatives have been reported as potent topoisomerase II (topo II) inhibitors, and preliminary structure-activity relationship (SAR) outcomes revealed that the linker between 1-NH and N-methyl piperazine motif of the… read more here.
Keywords: structural optimizations; optimizations bioevaluation; acridone derivatives; acridone ... See more keywords
New Acridone- and (Thio)Xanthone-Derived 1,1-Donor–Acceptor-Substituted Alkenes: pH-Dependent Fluorescence and Unusual Photooxygenation Properties
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DOI: 10.3390/molecules26113305
Abstract: A synthetic route to new heterocyclic 1,1-donor–acceptor-substituted alkenes starting with N-methyl-acridone, xanthone, and thioxanthone was investigated, leading to the acridone- and xanthone-derived products methyl 2-methoxy-2-(10-methylacridin-9 (10H)-ylidene)acetate (7) and methyl 2-methoxy-2-(9H-xanthen-9-ylidene)acetate (10) in low yields with… read more here.
Keywords: fluorescence; xanthone derived; donor acceptor; acceptor substituted ... See more keywords