Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2016.08.028
Abstract: ABSTRACT Acrolein is a highly toxic, volatile, unsaturated aldehyde generated during incomplete combustion as in tobacco smoke and indoor fires. Because the transient receptor potential ankyrin 1 (TRPA1) channel mediates tobacco smoke‐induced lung injury, we… read more here.
Keywords: high level; trpa1; level acrolein; mice ... See more keywords
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.153048
Abstract: Acrolein is a typical food and environmental pollutant and a risk factor for diabetes. The primary pathogenesis of diabetes is insulin deficiency and resistance. Ferroptosis is an iron-dependent cell death type, accompanying by lipid peroxide… read more here.
Keywords: min6 cells; insulin secretion; ferroptosis; stress ... See more keywords
Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45741
Abstract: Clinical studies report significant increases in acrolein (an α,β-unsaturated aldehyde) in the substantia nigra (SN) of patients with Parkinson’s disease (PD). In the present study, acrolein-induced neurotoxicity in the nigrostriatal dopaminergic system was investigated by… read more here.
Keywords: nigrostriatal dopaminergic; acrolein induced; synuclein aggregation; dopaminergic system ... See more keywords
P2X7 Receptor Blockade Protects Against Acrolein-Induced Bladder Damage: A Potential New Therapeutic Approach for the Treatment of Bladder Inflammatory Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.682520
Abstract: Inflammatory conditions of the urinary bladder have been shown to be associated with urothelial damage and loss of function. The purinergic P2X7 receptor has been implicated in several inflammatory conditions. The aim of this study… read more here.
Keywords: treatment; bladder; acrolein induced; damage ... See more keywords
Protective Effect of Purinergic P2X7 Receptor Inhibition on Acrolein-Induced Urothelial Cell Damage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.885545
Abstract: Patients undergoing chemotherapy with cyclophosphamide experience cystitis due to excretion of a toxic metabolite, acrolein. Cystitis, an inflammation of the bladder, is associated with damage to the integrity of the urothelial barrier. The purinergic P2X7… read more here.
Keywords: acrolein induced; cell; damage; urothelial cell ... See more keywords
Protective Effect of Ganoderma atrum Polysaccharide on Acrolein-Induced Apoptosis and Autophagic Flux in IEC-6 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11020240
Abstract: This study was designed to explore the beneficial effect and mechanism of Ganoderma atrum (G. atrum) polysaccharide (PSG-1) on acrolein-induced IEC-6 cells. Our results indicated that PSG-1 significantly reduced the impairment of acrolein on cell… read more here.
Keywords: acrolein induced; apoptosis; atrum; iec cells ... See more keywords
Chitooligosaccharides Derivatives Protect ARPE-19 Cells against Acrolein-Induced Oxidative Injury
Sign Up to like & getrecommendations! Published in 2023 at "Marine Drugs"
DOI: 10.3390/md21030137
Abstract: Age-related macular degeneration (AMD) is the leading cause of vision loss among the elderly. The progression of AMD is closely related to oxidative stress in the retinal pigment epithelium (RPE). Here, a series of chitosan… read more here.
Keywords: acrolein induced; protect arpe; chitooligosaccharides derivatives; arpe cells ... See more keywords