ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucida.
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DOI: 10.1093/humrep/dead059
Abstract: STUDY QUESTION Does a homozygous nonsense mutation in ACR lead to total fertilization failure (TFF) resulting in male infertility in humans? SUMMARY ANSWER A novel homozygous nonsense mutation of ACR (c.167G>A, p.Trp56X) was identified in… read more here.
Keywords: acrosin; fertilization; fertilization failure; acrosin deficiency ... See more keywords
Characterization of acrosin and acrosin binding protein as novel CRISP2 interacting proteins in boar spermatozoa.
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DOI: 10.1111/andr.13413
Abstract: BACKGROUND Previously we reported that cysteine rich secretory protein 2 (CRISP2) is involved in high molecular weight complexes in boar spermatozoa. These CRISP2 protein complexes are formed at the last phase of sperm formation in… read more here.
Keywords: crisp2; acrosin; boar spermatozoa; protein ... See more keywords