ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucida.
Sign Up to like & getrecommendations! Published in 2023 at "Human reproduction"
DOI: 10.1093/humrep/dead059
Abstract: STUDY QUESTION Does a homozygous nonsense mutation in ACR lead to total fertilization failure (TFF) resulting in male infertility in humans? SUMMARY ANSWER A novel homozygous nonsense mutation of ACR (c.167G>A, p.Trp56X) was identified in… read more here.
Keywords: acrosin; fertilization; fertilization failure; acrosin deficiency ... See more keywords