CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Human molecular genetics"
DOI: 10.1093/hmg/ddab185
Abstract: Asthenoteratospermia is a common cause of male infertility. Recent studies have revealed that CFAP65 mutations lead to severe asthenoteratospermia due to acrosome hypoplasia and flagellum malformations. However, the molecular mechanism underlying CFAP65-associated sperm malformation is… read more here.
Keywords: cfap65; spermiogenesis; acrosome biogenesis; mitochondrial sheath ... See more keywords
The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.09.15.508144
Abstract: The acrosome is a membranous organelle positioned in the anterior portion of sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles towards nascent acrosome which is regulated… read more here.
Keywords: spermatogenesis; acrosome biogenesis; biogenesis; mice ... See more keywords
Differential Expression and Localization of EHBP1L1 during the First Wave of Rat Spermatogenesis Suggest Its Involvement in Acrosome Biogenesis
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DOI: 10.3390/biomedicines10010181
Abstract: The identification and characterization of new proteins involved in spermatogenesis is fundamental, considering that good-quality gametes are basic in ensuring proper reproduction. Here, we further analyzed the temporal and spatial localization during the first spermatogenic… read more here.
Keywords: expression; wave rat; acrosome biogenesis; localization ... See more keywords