Interplay mechanisms between progesterone and endocannabinoid receptors in regulating bull sperm capacitation and acrosome reaction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30753
Abstract: After ejaculation, sperm show a limited capacity for transcription and translation. In the oviduct, most of the signalling in sperm is nongenomic and is mediated through membrane receptors. Studies have shown that the cation channel… read more here.
Keywords: interplay; capacitation acrosome; acrosome reaction; sperm capacitation ... See more keywords
NMDA‐type glutamate receptors mediate the acrosome reaction and motility initiation in newt sperm
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23225
Abstract: The N‐methyl d‐aspartate type glutamate receptor (NMDAR) is a ligand‐gated cation channel that causes Ca2+ influx in nerve cells. An NMDAR agonist is effective to the sperm motility in fowls, although the actual role of… read more here.
Keywords: acrosome reaction; reaction motility; motility; type glutamate ... See more keywords
Iberiotoxin and clofilium regulate hyperactivation, acrosome reaction, and ion homeostasis synergistically during human sperm capacitation
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23671
Abstract: Potassium channels play essential roles in the regulation of male fertility. However, potassium channels mediating K+ currents in human sperm (IKSper) remain controversial. Besides SLO3, the SLO1 potassium channel is a potential candidate for human… read more here.
Keywords: capacitation; hyperactivation; clofilium; acrosome reaction ... See more keywords
Neurotensin stimulates the sperm acrosome reaction and reduces percentages of fertilization in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Fertility and Sterility"
DOI: 10.1016/j.xfss.2020.03.001
Abstract: Objective To determine the impact of neurotensin (NTS), a naturally occurring peptide, on the function of human and nonhuman primate sperm. Design Experimental study. Setting University-based research laboratory. Patient(s)/Animal(s) Consenting normozoospermic human donors and cynomolgus… read more here.
Keywords: fertilization; acrosome reaction; neurotensin; sperm acrosome ... See more keywords
112 The effect of biological extenders on invitro induction of the acrosome reaction in bovine spermatozoa
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv32n2ab112
Abstract: Biological extenders in semen are used to protect the integrity of the sperm cells during cryopreservation. The two most common extenders are egg yolk and milk, and initial experiments describing heparin capacitation for IVF were… read more here.
Keywords: acrosome reaction; heparin capacitation; extender; reaction ... See more keywords
NUCB2/nesfatin-1 suppresses the acrosome reaction in sperm within the mouse epididymis
Sign Up to like & getrecommendations! Published in 2023 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2023.2212741
Abstract: ABSTRACT Nesfatin-1, a polypeptide hormone derived from the nucleobindin 2 (NUCB2) precursor protein, is known to regulate appetite and energy metabolism. Recent studies have also shown that NUCB2/nesfatin-1 is expressed in the reproductive organs of… read more here.
Keywords: mouse epididymis; acrosome reaction; nucb2; nucb2 nesfatin ... See more keywords
Platelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa
Sign Up to like & getrecommendations! Published in 2020 at "Andrologia"
DOI: 10.1111/and.13565
Abstract: Platelet‐activating factor (PAF) affects capacitation, acrosome reaction and fertilisation potential of spermatozoa. This study investigated the underlying mechanism(s) through which PAF regulated sperm function. Our data demonstrated that PAF dose‐dependently induced, whilst lyso‐PAF (PAF precursor)… read more here.
Keywords: paf; acrosome reaction; platelet activating; human spermatozoa ... See more keywords
Proteomic changes in human spermatozoa during in vitro capacitation and acrosome reaction in normozoospermia and asthenozoospermia
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13289
Abstract: The cellular and molecular mechanisms of the events that help spermatozoa acquire their fertilizing capability during capacitation and acrosome reaction are not completely understood. read more here.
Keywords: capacitation acrosome; changes human; acrosome reaction; proteomic changes ... See more keywords
Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade7607
Abstract: Spermatozoa need to undergo an exocytotic event called the acrosome reaction before fusing with eggs. Although calcium ion (Ca2+) is essential for the acrosome reaction, its molecular mechanism remains unknown. Ferlin is a single transmembrane… read more here.
Keywords: reaction; fer1l5 required; male fertility; acrosome reaction ... See more keywords
Proteomic Changes in Human Sperm During Sequential in vitro Capacitation and Acrosome Reaction
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00295
Abstract: The male gamete is not completely mature after ejaculation and requires further events in the female genital tract to acquire fertilizing ability, including the processes of capacitation and acrosome reaction. In order to shed light… read more here.
Keywords: protein; proteomic changes; acrosome reaction; capacitation acrosome ... See more keywords
Discrete Dynamic Model of the Mammalian Sperm Acrosome Reaction: The Influence of Acrosomal pH and Physiological Heterogeneity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.682790
Abstract: The acrosome reaction (AR) is an exocytotic process essential for mammalian fertilization. It involves diverse physiological changes (biochemical, biophysical, and morphological) that culminate in the release of the acrosomal content to the extracellular medium as… read more here.
Keywords: discrete dynamic; physiological heterogeneity; heterogeneity; acrosome reaction ... See more keywords