Active Transport of Biomimetic Cascaded Nanozymes Across Blood–Brain Barrier to Scavenge ROS and Alleviate Neuroinflammation Against Cerebral Ischemia Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202520000
Abstract: The rational design of potent antioxidative agents with active transport across blood–brain barrier (BBB) is critically required for mitigating ischemic reperfusion‐induced reactive oxygen species (ROS)‐mediated neuroinflammation and neural injury in ischemic stroke therapy. Herein, a… read more here.
Keywords: across blood; blood brain; active transport; reperfusion ... See more keywords
Quantification of water exchange across the blood‐brain barrier using noncontrast MR fingerprinting
Sign Up to like & getrecommendations! Published in 2024 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.30127
Abstract: A method is proposed to quantify cerebral blood volume ( vb$$ {v}_b $$ ) and intravascular water residence time ( τb$$ {\tau}_b $$ ) using MR fingerprinting (MRF), applied using a spoiled gradient echo sequence… read more here.
Keywords: across blood; exchange across; water; water exchange ... See more keywords
Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.04.008
Abstract: Objective The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks. One prevailing theory is that impaired transport of leptin across… read more here.
Keywords: blood brain; transport; leptin; across blood ... See more keywords
Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.04.040
Abstract: The importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in limiting the penetration of Mrp4 substrate compounds into the central nervous system across the blood-brain barrier was investigated using Mrp4-/- mice. Significant adenosine triphosphate-dependent uptake by… read more here.
Keywords: blood brain; across blood; mrp4; brain barrier ... See more keywords
Penetration of Organophosphate Triesters and Diesters across the Blood-Cerebrospinal Fluid Barrier: Efficiencies, Impact Factors, and Mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c01850
Abstract: The penetration of organophosphate triesters (tri-OPEs) and diesters (di-OPEs) across the blood-brain barrier and their influencing factors remain unclear in humans. In this study, 21 tri-OPEs and 8 di-OPEs were measured in 288 paired serum… read more here.
Keywords: penetration; barrier; penetration organophosphate; blood ... See more keywords
Delivering DNA Aptamers Across the Blood–Brain Barrier Reveals Heterogeneous Decreased ATP in Different Brain Regions of Alzheimer’s Disease Mouse Models
Sign Up to like & getrecommendations! Published in 2024 at "ACS Central Science"
DOI: 10.1021/acscentsci.4c00563
Abstract: DNA aptamers have been developed as sensors to detect metabolites with high sensitivity, selectivity, and biocompatibility. While they are effective in sensing important targets in the brain, the lack of methods for their efficient delivery… read more here.
Keywords: blood brain; brain; dna aptamers; brain barrier ... See more keywords
Material considerations for delivering therapeutics across the blood–brain barrier
Sign Up to like & getrecommendations! Published in 2025 at "APL Materials"
DOI: 10.1063/5.0284305
Abstract: Therapeutic drug delivery across the blood–brain barrier (BBB) has been a challenging feat for centuries. The intricate nature of the BBB is protected by multiple lines of defense through its neurovascular unit and subsequent junctions… read more here.
Keywords: blood brain; brain; brain barrier; across blood ... See more keywords
Functionalised LRP1 targeted carbon nanotubes across the blood-brain barrier in vitro and in vivo after intravenous injection
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz167.011
Abstract: Despite extensive research in drug development, brain cancer is still lacking an efficacious cure due to the inability to deliver current therapeutics to the brain across the blood-brain barrier (BBB). Chemically functionalized carbon nanotubes (f-CNT)… read more here.
Keywords: blood brain; vivo intravenous; carbon nanotubes; across blood ... See more keywords
Elastic jump propagation across a blood vessel junction
Sign Up to like & getrecommendations! Published in 2024 at "Royal Society Open Science"
DOI: 10.1098/rsos.232000
Abstract: The theory of small-amplitude waves propagating across a blood vessel junction has been well established with linear analysis. In this study, we consider the propagation of large-amplitude, nonlinear waves (i.e. shocks and rarefactions) through a… read more here.
Keywords: junction; vessel junction; blood vessel; vessel ... See more keywords
DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier.
Sign Up to like & getrecommendations! Published in 2020 at "Current pharmaceutical design"
DOI: 10.2174/1381612826666200213094556
Abstract: The use of peptides as drug carriers across the blood-brain barrier (BBB) has increased significantly during the last decades. PepH3, a seven residue sequence (AGILKRW) derived from the α-helical domain of the dengue virus type-2… read more here.
Keywords: receptor independent; across blood; blood brain; brain barrier ... See more keywords
Non-invasive gene delivery across the blood-brain barrier: present and future perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.320981
Abstract: Makes reference to several cell type specific/selective AAV vectors have been reported and mentions endothelial cells and astrocytes. Makes no reference to other cells oligodendrocytes or microglia which have also been successfully targeted with AAV… read more here.
Keywords: blood brain; invasive gene; across blood; non invasive ... See more keywords