Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114749
Abstract: For medicines, the apparent membrane permeability coefficients (Papp) across human colorectal carcinoma cell line (Caco-2) monolayers under a pH gradient generally correlate with the fraction absorbed after oral intake. Furthermore, the in vitro Papp values… read more here.
Keywords: machine learning; across intestinal; permeability; trivariate linear ... See more keywords
Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.220244
Abstract: Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation. For the present project, spherical gold nanoparticles were synthesized and functionalized with the… read more here.
Keywords: gold nanoparticles; muscarinic receptors; functionalized gold; across intestinal ... See more keywords
Fe3+ opposes the 1,25(OH)2D3-induced calcium transport across intestinal epithelium-like Caco-2 monolayer in the presence or absence of ascorbic acid
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0273267
Abstract: Although iron is an essential element for hemoglobin and cytochrome synthesis, excessive intestinal iron absorption—as seen in dietary iron supplementation and hereditary disease called thalassemia—could interfere with transepithelial transport of calcium across the intestinal mucosa.… read more here.
Keywords: calcium; calcium transport; iron; across intestinal ... See more keywords
Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.965200
Abstract: Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport. Live cell imaging could provide such mechanistic insights by… read more here.
Keywords: barrier; transport biologics; across intestinal; transport ... See more keywords