Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues
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DOI: 10.1016/j.cell.2017.08.024
Abstract: A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic map… read more here.
Keywords: across tissues; vaccination; level analysis; organism level ... See more keywords
Vertebrate Lineages Exhibit Diverse Patterns of Transposable Element Regulation and Expression across Tissues
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaa068
Abstract: Abstract Transposable elements (TEs) comprise a major fraction of vertebrate genomes, yet little is known about their expression and regulation across tissues, and how this varies across major vertebrate lineages. We present the first comparative… read more here.
Keywords: regulation across; expression; across tissues; vertebrate lineages ... See more keywords
Determinants of telomere length across human tissues
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aaz6876
Abstract: Telomere length within an individual varies in a correlated manner across most tissues. Telomere length within individuals Telomeres are DNA-protein complexes that protect chromosome ends. Their length is of great interest because short telomeres are… read more here.
Keywords: tissue types; age; telomere length; tissue ... See more keywords
Alternative splicing landscapes in Arabidopsis thaliana across tissues and stress conditions highlight major functional differences with animals
Sign Up to like & getrecommendations! Published in 2021 at "Genome Biology"
DOI: 10.1186/s13059-020-02258-y
Abstract: Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS in response to specific conditions, especially environmental stress, unveiling substantial amounts of intron… read more here.
Keywords: arabidopsis thaliana; gene expression; thaliana; across tissues ... See more keywords
Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans
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DOI: 10.1371/journal.pbio.3001431
Abstract: To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal heat shock factor… read more here.
Keywords: fat desaturation; desaturation; across tissues; neuronal hsf ... See more keywords
Embryonic ILC-poiesis across tissues
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1040624
Abstract: The family of innate lymphoid cells (ILCs), consisting of Group 1 ILCs (natural killer cells and ILC1), ILC2, and ILC3, are critical effectors of innate immunity, inflammation, and homeostasis post-natally, but also exert essential functions… read more here.
Keywords: embryonic ilc; poiesis across; across tissues; ilc poiesis ... See more keywords