Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102960
Abstract: In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a─q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of Aβ aggregation activities. The target compounds… read more here.
Keywords: acrylamide derivatives; alzheimer agents; flavone acrylamide; anti alzheimer ... See more keywords
Investigation of potent anticarcinogenic activity of 1, 3‐diarylpyrazole acrylamide derivatives in vitro
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DOI: 10.1111/jphp.13012
Abstract: Pyrazole derivatives are pharmacologically powerful agents pointing at new horizons in the development of anticancer therapies. In this study, anticarcinogenic potential of a series of pyrazole‐acrylamide derivatives has been investigated in mesothelial, malignant mesothelioma and… read more here.
Keywords: activity diarylpyrazole; acrylamide derivatives; anticarcinogenic activity; diarylpyrazole acrylamide ... See more keywords
Design and Synthesis of Newly Synthesized Acrylamide Derivatives as Potential Chemotherapeutic Agents against MCF-7 Breast Cancer Cell Line Lodged on PEGylated Bilosomal Nano-Vesicles for Improving Cytotoxic Activity
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DOI: 10.3390/ph14101021
Abstract: Cancer is a multifaceted disease. With the development of multi drug resistance, the need for the arousal of novel targets in order to avoid these drawbacks increased. A new series of acrylamide derivatives was synthesized… read more here.
Keywords: breast cancer; acrylamide derivatives; activity; cytotoxic activity ... See more keywords