Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors.
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DOI: 10.1039/c7md00571g
Abstract: The success of acrylamide-containing drugs in treating cancers has spurred a passion to search for acrylamide bioisosteres. In our endeavour, we have identified that an allenamide group can be a reactive bioisostere of the acrylamide… read more here.
Keywords: bioisostere acrylamide; design synthesis; covalent inhibitors; targeted covalent ... See more keywords