Ru-Catalyzed C-H Arylation of Acrylic Acids with Aryl Bromides.
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DOI: 10.1021/acs.orglett.2c01043
Abstract: In the presence of a [Ru(p-cymene)Cl2]2/triethylphosphine/lithium carbonate catalyst system, aryl bromides undergo (Z)-selective couplings with unprotected 2-arylacrylic acids to form (Z)-diarylacrylic acids. This vinylic C-H functionalization proceeds in high yields of up to 94% and… read more here.
Keywords: acrylic acids; acids aryl; arylation acrylic; catalyzed arylation ... See more keywords
One-Pot Construction of Heteroarylation/Esterification Products of Acrylic Acids via Iridium(III)-Catalyzed C-H Activation.
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DOI: 10.1021/acs.orglett.2c03245
Abstract: A carboxylate-assisted iridium(III)-catalyzed regioselective C(sp2)-H heteroarylation/esterification reaction of acrylic acid is disclosed herein for the first time. This catalytic protocol tolerates various α-substituted, β-substituted, and α, β-disubstituted acrylic acids as well as heteroaromatic boronates well.… read more here.
Keywords: acrylic acids; iridium iii; heteroarylation esterification; iii catalyzed ... See more keywords
Practical Synthesis of Phosphinic Dipeptides by Tandem Esterification of Aminophosphinic and Acrylic Acids under Silylating Conditions
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DOI: 10.3390/molecules27041242
Abstract: In this report, a synthetic protocol for the preparation of phosphinic dipeptides of type 5 is presented. These compounds serve as valuable building blocks for the development of highly potent phosphinopeptidic inhibitors of medicinally relevant… read more here.
Keywords: aminophosphinic acrylic; acrylic acids; acids silylating; phosphinic dipeptides ... See more keywords