Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor
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DOI: 10.1038/s41467-025-64183-7
Abstract: Acetyl-CoA synthetases (Acs) have emerged as drug targets for the treatment of cancer, metabolic diseases as well as fungal and parasitic infections. Although a variety of small molecule Acs inhibitors have been discovered, the systematic… read more here.
Keywords: acs inhibitors; coa; coa synthetases; mechanism ... See more keywords