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   Articles with "acsl4" as a keyword



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Therapeutic Targeting of Hepatic ACSL4 Ameliorates Non-alcoholic Steatohepatitis in Mice.

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recommendations! Published in 2021 at "Hepatology"

DOI: 10.1002/hep.32148

Abstract: Globally, NAFLD is one of the most common liver disorders, with an estimated prevalence rate of more than 30% in men and 15% in women, and an even higher prevalence in people with type 2… read more here.

Keywords: targeting hepatic; acsl4 ameliorates; acsl4; hepatic acsl4 ... See more keywords
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Acyl‐CoA synthetase‐4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy‐dependent transporter expression

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recommendations! Published in 2019 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.11.005

Abstract: &NA; Acyl‐CoA synthetase‐4 (ACSL4) is an enzyme implicated in estrogen receptor &agr; (ER&agr;) negative regulation and hormone therapy resistance in breast cancer. In addition, ACSL4 has been associated to certain types of hormone resistance in… read more here.

Keywords: drug resistance; acsl4; expression; resistance ... See more keywords
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ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway.

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recommendations! Published in 2020 at "Cancer letters"

DOI: 10.1016/j.canlet.2020.12.019

Abstract: Lipid metabolic reprogramming plays a pivotal role in hepatocellular carcinoma (HCC) development, but the underlying mechanisms are incompletely characterized. Long chain acyl CoA synthetase 4 (ACSL4), a member of acyl-CoA synthetases (ACS) family, has been… read more here.

Keywords: hepatocellular carcinoma; via myc; hcc; metabolism ... See more keywords
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CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axis

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recommendations! Published in 2022 at "Cell Cycle"

DOI: 10.1080/15384101.2022.2154543

Abstract: ABSTRACT Circular RNAs (CircRNAs) are reported to exert vital regulatory roles in the occurrence and development of various human malignancies, including non-small cell lung cancer (NSCLC). Bioinformatics methods identified the down-regulation of circSCN8A (circBase ID:… read more here.

Keywords: cell; circscn8a; non small; mir 1290 ... See more keywords
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ACSL4: a Double-edged Sword Target in Multiple Myeloma, Promotes Cell Proliferation and Sensitizes Cell to Ferroptosis.

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recommendations! Published in 2023 at "Carcinogenesis"

DOI: 10.1093/carcin/bgad015

Abstract: Overactive fatty acid metabolism is usually found in hematological malignancies including multiple myeloma (MM), but the underlying mechanisms remain unclear. Here, we reveal that acyl-CoA synthetase long-chain family member 4 (ACSL4) is abnormally over-expressed in… read more here.

Keywords: cell proliferation; acsl4; double edged; multiple myeloma ... See more keywords
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Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.02717-21

Abstract: We provide the first evidence for the role of ACSL4 in enterovirus replication organelle formation. Moreover, both enteroviruses and coronaviruses induce ferroptosis via ACSL4. These findings establish a novel regulatory mechanism for viral replication. The… read more here.

Keywords: ferroptosis; organelle formation; acsl4; enteroviruses coronaviruses ... See more keywords
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Tissue Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis.

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recommendations! Published in 2019 at "Endocrinology"

DOI: 10.1210/en.2019-00464

Abstract: ACSL4 is a member of the ACSL family that catalyzes the conversion of long chain fatty acids to acyl CoAs, which are essential for fatty acid incorporation and utilization into diverse metabolic pathways including cholesteryl… read more here.

Keywords: tissue specific; acsl4; cholesteryl ester; cholesteryl ... See more keywords
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Genetic Alteration, Prognostic and Immunological Role of Acyl-CoA Synthetase Long-Chain Family Member 4 in a Pan-Cancer Analysis

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.812674

Abstract: Acyl-CoA Synthetase long-chain family member 4 (ACSL4) is a member of acyl-CoA synthetase protein long-chain family, which is associated with amino acid synthesis, lipid synthesis and lipid peroxidation dependent iron death. However, the role of… read more here.

Keywords: expression; immune infiltration; pan cancer; acsl4 ... See more keywords