O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation
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DOI: 10.1038/s41388-022-02237-6
Abstract: Glioblastomas (GBMs) preferentially generate acetyl-CoA from acetate as a fuel source to promote tumor growth. O-GlcNAcylation has been shown to be elevated by increasing O-GlcNAc transferase (OGT) in many cancers and reduced O-GlcNAcylation can block… read more here.
Keywords: glcnac transferase; acss2 ser; phosphorylation; growth ... See more keywords