Aromatic Polyketide GTRI‐02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2)
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700107
Abstract: The biosynthesis of aromatic polyketides derived from type II polyketide synthases (PKSs) is complex, and it is not uncommon that highly similar gene clusters give rise to diverse structural architectures. The act biosynthetic gene cluster (BGC)… read more here.
Keywords: polyketide; act; gtri; gene cluster ... See more keywords
Design, Synthesis, and Optimization of Indole Acetic Acid Derivatives as Potent and Selective CRTH2 Receptor Antagonists: Discovery of ACT‐774312
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DOI: 10.1002/cmdc.202300007
Abstract: Herein we report the structure‐activity relationship (SAR) studies and optimization of new highly potent and selective CRTH2 receptor antagonists as potential follow‐ups of our previous reported clinical candidate setipiprant (ACT‐129968) for the treatment of respiratory… read more here.
Keywords: act; acetic acid; selective crth2; crth2 receptor ... See more keywords
Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs).
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.1980
Abstract: The multi-billion dollar dietary supplement industry is global in reach. The industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. In this review, we describe how the US Food… read more here.
Keywords: dietary supplements; act; dietary supplement; adulteration ... See more keywords
Longitudinal effects of adjuvant chemotherapy and related neuropathy on health utility in stage II and III colon cancer patients: A prospective cohort study
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DOI: 10.1002/ijc.33472
Abstract: Patient's quality of life should be included in clinical decision making regarding the administration of adjuvant chemotherapy (ACT) in stage II/III colon cancer. Therefore, quality of life, summarized as health utility (HU), was evaluated for… read more here.
Keywords: stage iii; patients treated; act; iii colon ... See more keywords
Translation of IDEA trial results into clinical practice: Analysis of the implementation of a new guideline for colon cancer
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DOI: 10.1002/ijc.34149
Abstract: The IDEA trial showed no clinical relevant differences in efficacy between 3 and 6 months of oxaliplatin‐based adjuvant chemotherapy (ACT) in colon cancer (CC), while toxicity was substantially lower in the 3 months regimen. Therefore,… read more here.
Keywords: guideline; act; stage; idea trial ... See more keywords
Prisoners of variants, or free to act as prisoners of swabs? The case of Italy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27597
Abstract: To the editor, " To all evils there are two remedies: time and silence [1]." This citation from The Count of Monte Cristo by Alexandre Dumas, written in 1844, in collaboration with Auguste Maquet, appears… read more here.
Keywords: free act; act prisoners; variants free; act ... See more keywords
Acceptance and Commitment Therapy for Major Depressive Disorder: Insights into a New Generation of Face-to-Face Treatment and Digital Self-Help Approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-33-6044-0_17
Abstract: Major depressive disorder (MDD) represents a key contributor to the global burden of mental illness given its relatively high lifetime prevalence, frequent comorbidity, and disability rates. Evidence-based treatment options for depression include pharmacotherapy and psychotherapy,… read more here.
Keywords: depressive disorder; act; treatment; major depressive ... See more keywords
Interaction potential of the dual orexin receptor antagonist ACT-541468 with CYP3A4 and food: results from two interaction studies
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2559-5
Abstract: PurposeACT-541468 is a novel dual orexin receptor antagonist (DORA) under development for the treatment of insomnia. In vitro studies suggested a significant role of CYP3A4 in ACT-541468 metabolism and an impact on CYP3A4 activity.MethodsSubsequently, two… read more here.
Keywords: act; act 541468; dual orexin; interaction ... See more keywords
Is Early Initiation of Adjuvant Chemotherapy Beneficial for Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiotherapy and Radical Surgery?
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DOI: 10.1007/s00268-020-05573-4
Abstract: Aim This study aimed to evaluate whether earlier initiation ( read more here.
Keywords: surgery; initiation; adjuvant chemotherapy; act ... See more keywords
A cohort of five cases with asymmetric conjoined twining and literature review
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DOI: 10.1007/s00383-021-05006-w
Abstract: Asymmetric conjoined twining (ACT) is a form of conjoined twining which is a rare malformation of monochorionic monoamniotic twin pregnancy. Most publications were single case reports. We reported a cohort of five cases with ACT… read more here.
Keywords: act; five cases; cohort five; asymmetric conjoined ... See more keywords
Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-022-00918-7
Abstract: Cancer therapies with anthracyclines have been shown to induce cardiovascular complications. The aims of this study were to establish an in vitro induced pluripotent stem cell model (iPSC) of anthracycline-induced cardiotoxicity (ACT) from patients with… read more here.
Keywords: cell lymphoma; cell model; act; cell ... See more keywords