Cell Surface‐Tethered Nucleic Acid Therapeutics Program Robust and Tumor‐Responsive Enhancement of Adoptive Cell Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202419969
Abstract: The efficacy of adoptive T cell therapy (ACT) against solid tumors is significantly limited by the immunosuppressive tumor microenvironment (TME). Systemic administration of immunostimulants provides inadequate support to ACT cells and often elicits systemic toxicities.… read more here.
Keywords: cell surface; cell; tumor; act ... See more keywords
Aromatic Polyketide GTRI‐02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2)
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700107
Abstract: The biosynthesis of aromatic polyketides derived from type II polyketide synthases (PKSs) is complex, and it is not uncommon that highly similar gene clusters give rise to diverse structural architectures. The act biosynthetic gene cluster (BGC)… read more here.
Keywords: polyketide; act; gtri; gene cluster ... See more keywords
Exploring the potential role of palladin in modulating human CAF/ECM functional units
Sign Up to like & getrecommendations! Published in 2024 at "Cytoskeleton"
DOI: 10.1002/cm.21926
Abstract: Fibroblasts, crucial for maintaining tissue homeostasis, significantly shape the tumor microenvironment (TME). In pancreatic cancer, a highly aggressive malignancy, cancer‐associated fibroblast (CAF)/extracellular matrix (ECM) units dominate the TME, influencing tumor initiation, progression, and treatment responses.… read more here.
Keywords: role; palladin; tumor; act ... See more keywords
Design, Synthesis, and Optimization of Indole Acetic Acid Derivatives as Potent and Selective CRTH2 Receptor Antagonists: Discovery of ACT‐774312
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300007
Abstract: Herein we report the structure‐activity relationship (SAR) studies and optimization of new highly potent and selective CRTH2 receptor antagonists as potential follow‐ups of our previous reported clinical candidate setipiprant (ACT‐129968) for the treatment of respiratory… read more here.
Keywords: act; acetic acid; selective crth2; crth2 receptor ... See more keywords
Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs).
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.1980
Abstract: The multi-billion dollar dietary supplement industry is global in reach. The industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. In this review, we describe how the US Food… read more here.
Keywords: dietary supplements; act; dietary supplement; adulteration ... See more keywords
The regulatory landscape of genetically engineered crops in Pakistan
Sign Up to like & getrecommendations! Published in 2024 at "Food and Energy Security"
DOI: 10.1002/fes3.494
Abstract: Genome editing technology has become part and parcel of biotechnological approach to understand the genetic basis of different biological processes in an organism and for its application in different fields. The basic need of world… read more here.
Keywords: genome edited; genetically engineered; edited crops; act ... See more keywords
Longitudinal effects of adjuvant chemotherapy and related neuropathy on health utility in stage II and III colon cancer patients: A prospective cohort study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33472
Abstract: Patient's quality of life should be included in clinical decision making regarding the administration of adjuvant chemotherapy (ACT) in stage II/III colon cancer. Therefore, quality of life, summarized as health utility (HU), was evaluated for… read more here.
Keywords: stage iii; patients treated; act; iii colon ... See more keywords
Translation of IDEA trial results into clinical practice: Analysis of the implementation of a new guideline for colon cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34149
Abstract: The IDEA trial showed no clinical relevant differences in efficacy between 3 and 6 months of oxaliplatin‐based adjuvant chemotherapy (ACT) in colon cancer (CC), while toxicity was substantially lower in the 3 months regimen. Therefore,… read more here.
Keywords: guideline; act; stage; idea trial ... See more keywords
What next for “counseling” in genetic counseling training: A co‐production workshop exploring how CBT and ACT approaches can contribute to the genetic counseling toolkit
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.1868
Abstract: Counseling techniques are an important part of genetic counseling, and teaching of the humanistic person‐centered philosophy has been central to genetic counselor (GC) training. However, other psychotherapeutic approaches, especially cognitive approaches, may also be beneficial… read more here.
Keywords: training; genetic counseling; counseling; cbt ... See more keywords
Prisoners of variants, or free to act as prisoners of swabs? The case of Italy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27597
Abstract: To the editor, " To all evils there are two remedies: time and silence [1]." This citation from The Count of Monte Cristo by Alexandre Dumas, written in 1844, in collaboration with Auguste Maquet, appears… read more here.
Keywords: free act; act prisoners; variants free; act ... See more keywords
Acceptance and Commitment Therapy for Major Depressive Disorder: Insights into a New Generation of Face-to-Face Treatment and Digital Self-Help Approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-33-6044-0_17
Abstract: Major depressive disorder (MDD) represents a key contributor to the global burden of mental illness given its relatively high lifetime prevalence, frequent comorbidity, and disability rates. Evidence-based treatment options for depression include pharmacotherapy and psychotherapy,… read more here.
Keywords: depressive disorder; act; treatment; major depressive ... See more keywords