Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1‐related nemaline myopathy (NEM3)
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DOI: 10.1002/ana.25144
Abstract: Nemaline myopathy (NM) is one of the most common congenital nondystrophic myopathies and is characterized by muscle weakness, often from birth. Mutations in ACTA1 are a frequent cause of NM (ie, NEM3). ACTA1 encodes alpha‐actin… read more here.
Keywords: contributes muscle; muscle weakness; acta1; weakness ... See more keywords
PCAF regulates cardiac muscle function via non-epigenetic regulation of ACTA1 acetylation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734987
Abstract: Historically, lysine acetylation has been studied in the epigenetic regulation of gene expression, in which it is known to play key roles in cardiac remodeling and dysfunction. However, recent evidence suggests that non-histone protein acetylation… read more here.
Keywords: acetylation; pcaf; acta1; physiology ... See more keywords