Abstract Or131: Novel epigenetic therapy for Smooth Muscle Dysfunction Syndrome
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.or131
Abstract: Missense pathogenic variants in ACTA2, encoding α-smooth muscle actin (SMA), predispose to thoracic aortic aneurysms, but pathogenic variants affecting the specific amino acid arginine 179 (R179) cause a more severe childhood onset phenotype termed Smooth… read more here.
Keywords: smcs; muscle; acta2; muscle dysfunction ... See more keywords
Sustained Downregulation of Vascular Smooth Muscle Acta2 After Transient Angiotensin II Infusion: A New Model of “Vascular Memory”
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.854361
Abstract: Background Activation of the renin-angiotensin-aldosterone system (RAAS) plays a critical role in the development of hypertension. Published evidence on a putative “memory effect” of AngII on the vascular components is however scarce. Aim To evaluate… read more here.
Keywords: sustained downregulation; acta2; downregulation; infusion ... See more keywords