Structure Based Screening for Inhibitory Therapeutics of CTLA-4 Unveiled New Insights About Biology of ACTH
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09891-7
Abstract: Although the biology of adrenocorticotropic hormone (ACTH) protein has already been scrutinized, some functional aspects of its biology are yet to be elucidated in the context of immunological disorders. In this regard, virtual screening of… read more here.
Keywords: ctla; structure based; biology; acth ... See more keywords
Human anterior pituitary’s ACTH cells during the aging process: immunohistochemic and morphometric study
Sign Up to like & getrecommendations! Published in 2020 at "Anatomical Science International"
DOI: 10.1007/s12565-020-00583-7
Abstract: Corticotrophs produce a hormone that stimulates the adrenal gland cortex to secrete glucocorticoids, which in turn have effects on carbohydrate and protein metabolism. Quantification, morphological characteristics, and distribution of corticotrophs in the anterior pituitary and… read more here.
Keywords: human anterior; volume; volume density; cells aging ... See more keywords
Tumeur neuroendocrine pulmonaire sécrétrice d’ACTH avec expression clinique tardive
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.837
Abstract: Introduction Les tumeurs neuroendocrines (TNE) secretrices d’ACTH sont generalement diagnostiquees lors du bilan etiologique d’un hypercorticisme ACTH dependant. Aucun article dans la litterature ne mentionne une tumeur ne s’exprimant cliniquement qu’apres plusieurs annees d’evolution. Observation… read more here.
Keywords: tumeur neuroendocrine; hypercorticisme; clinique; neuroendocrine pulmonaire ... See more keywords
Evaluation of Plasma ACTH Stability using the Roche Elecsys Immunoassay.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2020.04.004
Abstract: BACKGROUND Adrenocorticotropic hormone (ACTH) has been reported to be labile in blood due to proteolytic degradation and stringent procedures are followed to prevent in vitro degradation after sample collection. OBJECTIVE The purpose of this study… read more here.
Keywords: plasma acth; plasma; roche elecsys; acth ... See more keywords
AQB-565 shows promise in preclinical testing in the model of epileptic spasms during infancy: Head-to-head comparison with ACTH
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.03.004
Abstract: Epileptic spasms during infancy (infantile spasms) represent a serious treatment and social problem despite their rare occurrence. Current treatments include hormonal therapy (adrenocorticotropin-ACTH or corticosteroids) or vigabatrin (per se or in the combination). These treatments… read more here.
Keywords: spasms infancy; infantile spasms; epileptic spasms; aqb 565 ... See more keywords
Changes in adrenal functioning induced by chronic psychosocial stress in male mice: A time course study
Sign Up to like & getrecommendations! Published in 2020 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2020.104880
Abstract: BACKGROUND AND AIM Chronic subordinate colony housing (CSC, 19 days), an established and preclinically-validated mouse model for posttraumatic stress disorder (PTSD), causes evening hypocorticism and a reduced adrenal in vitro ACTH (adrenocorticotropic hormone) sensitivity despite… read more here.
Keywords: exposure; time; stress; acth ... See more keywords
Identifying Glucocorticoid Insufficiency in Silent Corticotroph Adenoma with Elevated Adrenocorticotropic Hormone.
Sign Up to like & getrecommendations! Published in 2021 at "Laboratory medicine"
DOI: 10.1093/labmed/lmab053
Abstract: Silent corticotroph adenoma (SCA) is as an aggressive pituitary tumor. A 48 year old man developed hypogonadotrophic hypogonadism. The basal morning adrenocorticotropic hormone (ACTH) was elevated, but the basal morning and peak after ACTH (1-24)… read more here.
Keywords: silent corticotroph; corticotroph adenoma; adrenocorticotropic hormone; acth ... See more keywords
GENE-23. GENOME-WIDE DNA METHYLATION PROFILES DISTINGUISH SILENT FROM NON-SILENT ACTH ADENOMAS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.425
Abstract: BACKGROUND Corticotroph adenomas are immunopositive for adrenocorticotrophic hormone (ACTH) associated with elevated blood ACTH levels leading to Cushing disease (CD). Yet silent ACTH adenomas (SCA) immunostain for ACTH but do not cause hypercortisolism. SCA have… read more here.
Keywords: genome wide; methylation; sca; acth ... See more keywords
FSGS ACTH Gel: Part of the Answer?
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation"
DOI: 10.1097/tp.0000000000002321
Abstract: In this issue, T. Alhamad et al1 retrospectively reviewed 20 cases of posttransplant recurrent and de novo focal segmental glomerular sclerosis (FSGS) treated by an adrenocorticotropic hormone (ACTH) analogue gel.FSGS recurrence has been reported in… read more here.
Keywords: acth gel; acth; part answer; fsgs ... See more keywords
Plasma adrenocorticotropic hormone (ACTH) concentrations in ponies measured by two different assays suggests seasonal cross‐reactivity or interference
Sign Up to like & getrecommendations! Published in 2018 at "Equine Veterinary Journal"
DOI: 10.1111/evj.12797
Abstract: BACKGROUND Analysis of plasma adrenocorticotropic hormone concentration [ACTH] aids diagnosis of pituitary pars intermedia dysfunction (PPID). Comparisons of the validated chemiluminescent-immunoassay (CI) and immunofluorescent (IF) assays are limited. OBJECTIVES To compare the results of [ACTH]… read more here.
Keywords: spring; plasma adrenocorticotropic; cross reactivity; acth ... See more keywords
An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production
Sign Up to like & getrecommendations! Published in 2020 at "Case Reports in Endocrinology"
DOI: 10.1155/2020/2025631
Abstract: Introduction. Adrenocortical carcinomas (ACCs) are infrequently reported to present with severe hypoglycemia syndrome resulting from the secretion of insulin-like growth factor II (IGF-II) by tumor cells. Adrenocorticotropic hormone- (ACTH) independent hypercortisolism is the norm of… read more here.
Keywords: adrenocortical carcinoma; tumor; hypoglycemia; acth production ... See more keywords