ACTH-secreting pituitary carcinoma with TP53, NF1, ATRX and PTEN mutations Case report and review of the literature
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine"
DOI: 10.1007/s12020-021-02954-0
Abstract: Pituitary carcinoma (PC) is a very rare tumor entity of the sella turcica, representing 0.1–0.5% of all PitNETs tumors [1–5]. Based on the WHO Classification, it is defined as pituitary tumor with confirmed craniospinal and/or… read more here.
Keywords: tumor; case; acth secreting; tp53 nf1 ... See more keywords
ACTH secreting pituitary carcinoma: Rare, durable response to concurrent chemotherapy and re-irradiation with a review of the literature. Recurrent pituitary carcinoma re-irradiation
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Radiation Oncology"
DOI: 10.1016/j.adro.2021.100813
Abstract: Abstract Pituitary carcinoma (PC) is an uncommon intracranial malignancy with a high rate of metastasis, mortality, and inconsistent response to therapy. Because PC is a rare condition (0.1%-0.2% of pituitary tumors), prospective studies and observable… read more here.
Keywords: irradiation; carcinoma; response; secreting pituitary ... See more keywords
A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103368
Abstract: The pituitary gland is a master endocrine organ composed of distinct hormone-producing cell types that serve as sensors to integrate central and peripheral signals in order to fine-tune whole-body homeostasis and control multiple physiological functions… read more here.
Keywords: cushing disease; novel human; cell cultures; cell ... See more keywords
An ACTH-secreting tumour hidden in a congenitally hypoplastic left lung
Sign Up to like & getrecommendations! Published in 2022 at "Interactive Cardiovascular and Thoracic Surgery"
DOI: 10.1093/icvts/ivac130
Abstract: Abstract Ectopic adrenocorticotrophic hormone (ACTH) syndrome has historically been a therapeutic challenge because of the difficulty localizing occult ACTH-secreting tumours. Here, we report a case of a 67-year-old woman with ectopic ACTH syndrome and had… read more here.
Keywords: left lung; tumour hidden; acth secreting; hypoplastic left ... See more keywords
ACTH-Secreting Renal Neuroendocrine Tumor on 68Ga-DOTATATE PET/CT.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004595
Abstract: ABSTRACT Adrenocorticotropic hormone (ACTH)-secreting renal neuroendocrine tumor (NET) is extremely rare. A left renal mass was detected on ultrasound in a 26-year-old patient with ACTH-dependent Cushing syndrome. The lesion demonstrated slightly high density and moderate… read more here.
Keywords: acth secreting; neuroendocrine tumor; 68ga dotatate; renal neuroendocrine ... See more keywords
Contrast-enhanced 3D-T2-weighted SPACE sequence for MRI detection and localization of adrenocorticotropin (ACTH) -secreting pituitary microadenomas.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical endocrinology"
DOI: 10.1111/cen.14574
Abstract: OBJECTIVE Cushing disease is a potentially fatal endocrine disorder caused by adrenocorticotropin (ACTH) -secreting microadenomas in the pituitary gland. Accurate detection and localization of the adenomas is the key to clinical treatment. This study analyzed… read more here.
Keywords: space; space sequence; secreting pituitary; contrast enhanced ... See more keywords
ACTH-secreting metastatic prostate cancer with neuroendocrine differentiation
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2021-247997
Abstract: Cushing’s syndrome (CS) due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) can result from a variety of tumours and rarely from those of prostatic origin. We present a male patient in his early 60s with… read more here.
Keywords: neuroendocrine differentiation; acth secreting; metastatic prostate; secreting metastatic ... See more keywords
Subclinical Hemorrhage of ACTH-secreting Pituitary Adenomas in Children and Adolescents Changes Their Biochemical Profile.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvac080
Abstract: Context Subclinical pituitary hemorrhage, necrosis, and/or cystic degeneration (SPH) presents mainly in large tumors and prolactinomas. The characteristics of patients with Cushing disease (CD) and SPH are not known. Objective To determine if SPH affects… read more here.
Keywords: acth secreting; without sph; sph; biochemical profile ... See more keywords
Case Report: Micro-RNAs in Plasma From Bilateral Inferior Petrosal Sinus Sampling and Peripheral Blood From Corticotroph Pituitary Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.748152
Abstract: Objective Circulating miRNAs are found in bodily fluids including plasma and can serve as biomarkers for diseases. The aim of this study was to provide the first insight into the landscape of circulating miRNAs in… read more here.
Keywords: pitnet patients; inferior petrosal; acth secreting; pitnet ... See more keywords
Identification of Novel Genes Involved in the Pathogenesis of an ACTH-Secreting Pituitary Carcinoma: A Case Report and Literature Review
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DOI: 10.3389/fonc.2018.00510
Abstract: Pituitary carcinomas (PCs) is considerable uncommon entities with a poor prognosis that represents only 0. 1–0.2% of all pituitary tumors. There are fewer than 150 reported cases up to now. In addition, the molecular pathogenesis… read more here.
Keywords: genes involved; novel genes; case; pathogenesis ... See more keywords
P720R USP8 Mutation Is Associated with a Better Responsiveness to Pasireotide in ACTH-Secreting PitNETs
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14102455
Abstract: Simple Summary Somatic mutations in USP8 gene have been identified in 11–60% of patients with ACTH-secreting pituitary tumors. This study investigated the impact of USP8 mutations on corticotroph tumor cells responsiveness to the treatment with… read more here.
Keywords: usp8 mutation; acth secreting; p720r usp8; tumor cells ... See more keywords