KIF14 as a Dual Microtubule/F-Actin Binding Protein Contributing to Cytokinesis.
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.70020
Abstract: Cytokinesis, the final step of cell division, necessitates precise coordination between the microtubule-based central spindle and the actomyosin contractile ring. KIF14, a member of the kinesin-3 family of motor proteins, has emerged as a crucial… read more here.
Keywords: microtubule actin; cytokinesis; actin binding; kif14 dual ... See more keywords
Drebrin in Renal Glomeruli.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-4-431-56550-5_20
Abstract: The central function of renal glomeruli is plasma ultrafiltration for primary urine production. The glomerular filtration barrier consists of a fenestrated endothelium, the glomerular basement membrane and podocytes, mesenchymal-like cells with actin filament-rich protrusions, the… read more here.
Keywords: foot processes; renal glomeruli; actin binding; microscopy ... See more keywords
Unidirectional cooperative binding of fimbrin actin-binding domain 2 to actin filament.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.139
Abstract: Fimbrin forms bundles of parallel actin filaments in filopodia, but it remains unclear how fimbrin forms well-ordered bundles. To address this issue, we focused on the cooperative interaction between the actin-binding domain of fimbrin and… read more here.
Keywords: binding domain; actin; actin binding; fimbrin ... See more keywords
Presence of actin binding motif in VgrG-1 toxin of Vibrio cholerae reveals the molecular mechanism of actin cross-linking.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.04.026
Abstract: Type VI secretion systems (T6SS) plays a crucial role in Vibrio cholerae mediated pathogenicity. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 bacteriophage. VgrG-1 of V. cholerae T6SS is unusual… read more here.
Keywords: actin; actin cross; actin binding; cross linking ... See more keywords
Synthesis of First Coumarin Fluorescent Dye for Actin Visualization.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00332
Abstract: Selective fluorescence imaging of actin protein hugely depends on the fluorescently labeled actin-binding domain (ABD). Thus, it is always a challenging task to image the actin protein (in vivo or in vitro) directly with an… read more here.
Keywords: actin binding; actin; actin protein; dye ... See more keywords
β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05762-2
Abstract: Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem calponin homology domains… read more here.
Keywords: high affinity; actin binding; affinity actin; iii spectrin ... See more keywords
A red fluorescent lifeact marker to study actin morphology in podocytes
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-025-96822-w
Abstract: F-actin is a major component of the cellular cytoskeleton, responsible for maintaining cell shape, enabling movement and facilitating intracellular transport. In the kidney, glomerular podocytes are highly dependent on their actin cytoskeleton shaping their unique… read more here.
Keywords: red fluorescent; study actin; microscopy; actin binding ... See more keywords
A conformational change in α-catenin’s actin-binding domain governs adherens junction maturation
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08785-3
Abstract: The formation and maintenance of epithelia is critical for animal development and survival. Central to epithelial integrity are cadherin-based complexes called adherens junctions (AJs), which form physically robust but inherently dynamic cell-cell adhesions. How AJs… read more here.
Keywords: maturation; actin binding; catenin; conformational change ... See more keywords
Development of novel therapeutics for the treatment of glaucoma based on actin-binding kinase inhibition – in silico approach
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/c9nj05967a
Abstract: Actin-binding kinases are enzymes involved in the regulation of actin polymerization and microtubule disassembly. The inhibition of actin-binding kinases can be used in the treatment of glaucoma, since it relaxes the tissue, increases outflow facility,… read more here.
Keywords: treatment glaucoma; actin binding; binding kinase; inhibition ... See more keywords
A multiscale biophysical model for the recruitment of actin nucleating proteins at the membrane interface.
Sign Up to like & getrecommendations! Published in 2020 at "Soft matter"
DOI: 10.1039/d0sm00267d
Abstract: The dynamics and organization of the actin cytoskeleton are crucial to many cellular events such as motility, polarization, cell shaping, and cell division. The intracellular and extracellular signaling associated with this cytoskeletal network is communicated… read more here.
Keywords: multiscale biophysical; proteins membrane; binding proteins; biophysical model ... See more keywords
The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109329119
Abstract: Significance Talin is a mechanosensitive adaptor protein that links integrins to the actin cytoskeleton at cell–extracellular matrix adhesions. Although the C-terminal actin-binding domain ABS3 of talin is required for function, it binds weakly to actin… read more here.
Keywords: actin; terminal actin; binding domain; actin binding ... See more keywords