Drebrin in Renal Glomeruli.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-4-431-56550-5_20
Abstract: The central function of renal glomeruli is plasma ultrafiltration for primary urine production. The glomerular filtration barrier consists of a fenestrated endothelium, the glomerular basement membrane and podocytes, mesenchymal-like cells with actin filament-rich protrusions, the… read more here.
Keywords: foot processes; renal glomeruli; actin binding; microscopy ... See more keywords
Unidirectional cooperative binding of fimbrin actin-binding domain 2 to actin filament.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.139
Abstract: Fimbrin forms bundles of parallel actin filaments in filopodia, but it remains unclear how fimbrin forms well-ordered bundles. To address this issue, we focused on the cooperative interaction between the actin-binding domain of fimbrin and… read more here.
Keywords: binding domain; actin; actin binding; fimbrin ... See more keywords
Presence of actin binding motif in VgrG-1 toxin of Vibrio cholerae reveals the molecular mechanism of actin cross-linking.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.04.026
Abstract: Type VI secretion systems (T6SS) plays a crucial role in Vibrio cholerae mediated pathogenicity. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 bacteriophage. VgrG-1 of V. cholerae T6SS is unusual… read more here.
Keywords: actin; actin cross; actin binding; cross linking ... See more keywords
Synthesis of First Coumarin Fluorescent Dye for Actin Visualization.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00332
Abstract: Selective fluorescence imaging of actin protein hugely depends on the fluorescently labeled actin-binding domain (ABD). Thus, it is always a challenging task to image the actin protein (in vivo or in vitro) directly with an… read more here.
Keywords: actin binding; actin; actin protein; dye ... See more keywords
β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05762-2
Abstract: Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem calponin homology domains… read more here.
Keywords: high affinity; actin binding; affinity actin; iii spectrin ... See more keywords
Development of novel therapeutics for the treatment of glaucoma based on actin-binding kinase inhibition – in silico approach
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/c9nj05967a
Abstract: Actin-binding kinases are enzymes involved in the regulation of actin polymerization and microtubule disassembly. The inhibition of actin-binding kinases can be used in the treatment of glaucoma, since it relaxes the tissue, increases outflow facility,… read more here.
Keywords: treatment glaucoma; actin binding; binding kinase; inhibition ... See more keywords
A multiscale biophysical model for the recruitment of actin nucleating proteins at the membrane interface.
Sign Up to like & getrecommendations! Published in 2020 at "Soft matter"
DOI: 10.1039/d0sm00267d
Abstract: The dynamics and organization of the actin cytoskeleton are crucial to many cellular events such as motility, polarization, cell shaping, and cell division. The intracellular and extracellular signaling associated with this cytoskeletal network is communicated… read more here.
Keywords: multiscale biophysical; proteins membrane; binding proteins; biophysical model ... See more keywords
The C-terminal actin-binding domain of talin forms an asymmetric catch bond with F-actin
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109329119
Abstract: Significance Talin is a mechanosensitive adaptor protein that links integrins to the actin cytoskeleton at cell–extracellular matrix adhesions. Although the C-terminal actin-binding domain ABS3 of talin is required for function, it binds weakly to actin… read more here.
Keywords: actin; terminal actin; binding domain; actin binding ... See more keywords
Discovery of ultrafast myosin, its amino acid sequence, and structural features
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120962119
Abstract: Significance It has been suggested for more than 50 y that the fastest myosin in the biological world with a velocity of 70 μm s−1 exists in the alga Chara, because cytoplasmic streaming with a… read more here.
Keywords: cbxi; actin binding; velocity; myosin ... See more keywords
The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/4578373
Abstract: Metastasis causes death of 90% of cancer patients, so it is the most significant issue associated with cancer disease. Thus, it is no surprise that many researchers are trying to develop drugs targeting or preventing… read more here.
Keywords: binding proteins; transition; actin binding; epithelial mesenchymal ... See more keywords
Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/9516808
Abstract: Background Glioma is the most prevalent malignant brain tumor in adult humans, and glioblastoma (GBM) is the most malignant type. The actin-binding LIM 1 (ABLIM1) protein can modulate actin polymerization, which is essential for the… read more here.
Keywords: actin binding; binding lim; tumor; lim ablim1 ... See more keywords