Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/s41556-017-0030-y
Abstract: A robust nanopillar platform with increased spatial resolution reveals that perinuclear forces, originating from stress fibres spanning the nucleus of fibroblasts, are significantly higher on these nanostructured substrates than the forces acting on peripheral adhesions.… read more here.
Keywords: force measurements; measurements reveal; nanopillar force; actin cap ... See more keywords
Anisotropy vs isotropy in living cell indentation with AFM
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42077-1
Abstract: The measurement of local mechanical properties of living cells by nano/micro indentation relies on the foundational assumption of locally isotropic cellular deformation. As a consequence of assumed isotropy, the cell membrane and underlying cytoskeleton are… read more here.
Keywords: actin cap; indentation; deformation; isotropy ... See more keywords
Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington’s disease patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1013721
Abstract: Primary fibroblasts from patient’s skin biopsies are directly isolated without any alteration in the genome, retaining in culture conditions their endogenous cellular characteristics and biochemical properties. The aim of this study was to identify a… read more here.
Keywords: disease patients; huntington disease; primary fibroblasts; cap ... See more keywords