Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS open bio"
DOI: 10.1002/2211-5463.70083
Abstract: In addition to transmitting receptor-mediated signals to adjust the gene expression profile of the cell, small GTPases of the Ras family also control the remodelling of the actin cytoskeleton. The conversion of Ras GTPases from… read more here.
Keywords: controlled iqgc; dynamics controlled; rasgap crossroads; rasgap ... See more keywords
MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.05.048
Abstract: Summary APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to… read more here.
Keywords: spatial organization; activation; myo6 regulates; signaling endosomes ... See more keywords
ARAP1 Bridges Actin Dynamics and AP-3-Dependent Membrane Traffic in Bone-Digesting Osteoclasts
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.07.019
Abstract: Summary Bone-resorbing osteoclasts play a central role in bone remodeling and its pathology. To digest bone, osteoclasts re-organize both F-actin, to assemble podosomes/sealing zones, and membrane traffic, to form bone-facing ruffled borders enriched in lysosomal… read more here.
Keywords: membrane traffic; bridges actin; bone; actin dynamics ... See more keywords
WDR1-regulated actin dynamics is required for outflow tract and right ventricle development.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.04.004
Abstract: Outflow tract (OFT) anomalies account for about 30% of human congenital heart defects detected at birth. The second heart field (SHF) progenitors contribute to OFT and right ventricle (RV) development, but the process largely remains… read more here.
Keywords: ventricle development; outflow tract; wdr1; actin dynamics ... See more keywords
Photoconversion of FM1-43 Reveals Differences in Synaptic Vesicle Recycling and Sensitivity to Pharmacological Disruption of Actin Dynamics in Individual Synapses.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00712
Abstract: The cycling of synaptic vesicles ensures that neurons can communicate adequately through their synapses on repeated occasions when activity is sustained, and several steps in this cycle are modulated by actin. The effects of pharmacological… read more here.
Keywords: vesicle; actin; vesicle recycling; photoconversion ... See more keywords
PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-0184-9
Abstract: PSGL-1 has recently been identified as an HIV restriction factor that inhibits HIV DNA synthesis and more potently, virion infectivity. But the underlying mechanisms of these inhibitions are unknown. Here we show that PSGL-1 directly… read more here.
Keywords: hiv infection; hiv; envelope; psgl inhibits ... See more keywords
Ciliary tip actin dynamics regulate photoreceptor outer segment integrity
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DOI: 10.1038/s41467-024-48639-w
Abstract: As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (discs) at the tip… read more here.
Keywords: outer segment; actin dynamics; photoreceptor; actin ... See more keywords
Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35204-x
Abstract: Calpain-10 (CAPN10) is the calpain family protease identified as the first candidate susceptibility gene for type 2 diabetes mellitus (T2DM). However, the detailed molecular mechanism has not yet been elucidated. Here we report that CAPN10… read more here.
Keywords: associated protein; microtubule associated; calpain regulates; family ... See more keywords
Nance-Horan-syndrome-like 1b controls mesodermal cell migration by regulating protrusion and actin dynamics during zebrafish gastrulation
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-025-07689-6
Abstract: Cell migrations are crucial for embryonic development, wound healing, the immune response, as well as for cancer progression. During mesenchymal cell migration, the Rac1-WAVE-Arp2/3 signalling pathway induces branched actin polymerisation, which protrudes the membrane and… read more here.
Keywords: migration; protrusion; cell migration; cell ... See more keywords
Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41434
Abstract: Tumour-associated macrophages mainly comprise immunosuppressive M2 phenotypes that promote tumour progression besides anti-tumoural M1 subsets. Selective depletion or reprogramming of M2 may represent an innovative anti-cancer strategy. The actin cytoskeleton is central for cellular homeostasis… read more here.
Keywords: dynamics potential; cha; strategy; actin dynamics ... See more keywords
STK16 regulates actin dynamics to control Golgi organization and cell cycle
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44607
Abstract: STK16 is a ubiquitously expressed, myristoylated, and palmitoylated serine/threonine protein kinase with underexplored functions. Recently, it was shown to be involved in cell division but the mechanism remains unclear. Here we found that human STK16… read more here.
Keywords: cell cycle; stk16; regulates actin; cell ... See more keywords