A solution to the long-standing problem of actin expression and purification
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209150119
Abstract: Significance Actin plays essential roles in cellular processes such as muscle contraction, cell motility, and cytokinesis. Humans express six noninterchangeable actin isoforms. Mutations in all the isoforms have been linked to devastating human diseases. Despite… read more here.
Keywords: standing problem; problem actin; solution long; actin ... See more keywords
Progressive Reduction in Right Ventricular Contractile Function Attributable to Altered Actin Expression in an Aging Mouse Model of Arrhythmogenic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.120.049261
Abstract: Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited genetic disorder of desmosomal dysfunction, and PKP2 (plakophilin-2) has been reported to be the most common disease-causing gene when mutation-positive. In the early concealed phase, the ACM heart… read more here.
Keywords: pkp2 het; pkp2; actin expression; contraction ... See more keywords
Desmoglein 2 mutation provokes skeletal muscle actin expression and accumulation at intercalated discs in murine hearts
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.199612
Abstract: ABSTRACT Arrhythmogenic cardiomyopathy (AC) is an incurable progressive disease that is linked to mutations in genes coding for components of desmosomal adhesions that are localized to the intercalated disc region, which electromechanically couples adjacent cardiomyocytes.… read more here.
Keywords: skeletal muscle; muscle actin; actin expression;