The proline‐rich domain of fission yeast WASp (Wsp1p) interacts with actin filaments and inhibits actin polymerization
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14571
Abstract: Members of the Wiskott–Aldrich Syndrome protein (WASp) family activate Arp2/3 complex (actin‐related proteins 2 and 3 complex) to form actin filament branches. The proline‐rich domain (PRD) of WASp contributes to branching nucleation, and the PRD… read more here.
Keywords: actin filaments; rich domain; proline rich; actin ... See more keywords
Actin Filaments Couple the Protrusive Tips to the Nucleus through the I‐BAR Domain Protein IRSp53 during the Migration of Cells on 1D Fibers
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207368
Abstract: The cell migration cycle, well‐established in 2D, proceeds with forming new protrusive structures at the cell membrane and subsequent redistribution of contractile machinery. Three‐dimensional (3D) environments are complex and composed of 1D fibers, and 1D… read more here.
Keywords: cell; irsp53; actin filaments; filaments couple ... See more keywords
Actin filaments modulate electrical activity of brain microtubule protein two‐dimensional sheets
Sign Up to like & getrecommendations! Published in 2020 at "Cytoskeleton"
DOI: 10.1002/cm.21596
Abstract: The cytoskeleton of eukaryotic cells contains networks of actin filaments and microtubules (MTs) that are jointly implicated in various cell functions, including cell division, morphogenesis, and migration. In neurons, this synergistic activity drives both the… read more here.
Keywords: microtubule protein; two dimensional; dimensional sheets; brain microtubule ... See more keywords
Impaired actin filaments decrease cisplatin sensitivity via dysfunction of volume‐sensitive Cl− channels in human epidermoid carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29767
Abstract: Cisplatin is a widely used platinum‐based anticancer drug in the chemotherapy of numerous human cancers. However, cancer cells acquire resistance to cisplatin. So far, functional loss of volume‐sensitive outwardly rectifying (VSOR) Cl− channels has been… read more here.
Keywords: human epidermoid; volume; cisplatin; epidermoid carcinoma ... See more keywords
Cytoskeleton Observation in Phototropism and Polarotropism of Adiantum Protonema.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9015-3_15
Abstract: The distribution patterns of the cytoskeleton, i.e., microtubules and actin filaments, in the apical part of protonemal cells are unique and differ from those of other apical growing cells, such as moss and liverwort protonemata,… read more here.
Keywords: phototropism polarotropism; microtubules actin; polarotropism adiantum; observation phototropism ... See more keywords
Differentiation-dependent rearrangements of actin filaments and microtubules hinder apical endocytosis in urothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-017-1566-4
Abstract: During differentiation, superficial urothelial cells (UCs) of the urinary bladder form the apical surface, which is almost entirely covered by urothelial plaques containing densely packed uroplakin particles. These urothelial plaques are the main structural components… read more here.
Keywords: differentiated ucs; apical endocytosis; endocytosis; urothelial cells ... See more keywords
The advantages of microfluidics to study actin biochemistry and biomechanics
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Muscle Research and Cell Motility"
DOI: 10.1007/s10974-019-09564-4
Abstract: The regulated assembly of actin filaments is essential in nearly all cell types. Studying actin assembly dynamics can pose many technical challenges. A number of these challenges can be overcome by using microfluidics to observe… read more here.
Keywords: biochemistry; study actin; biomechanics; actin filaments ... See more keywords
Arabidopsis AIP1-1 regulates the organization of apical actin filaments by promoting their turnover in pollen tubes
Sign Up to like & getrecommendations! Published in 2019 at "Science China Life Sciences"
DOI: 10.1007/s11427-019-9532-0
Abstract: Apical actin filaments are highly dynamic structures that are crucial for rapid pollen tube growth, but the mechanisms regulating their dynamics and spatial organization remain incompletely understood. We here identify that AtAIP1-1 is important for… read more here.
Keywords: actin; apical actin; pollen tubes; actin filaments ... See more keywords
The βγ subunit of heterotrimeric G proteins interacts with actin filaments during neuronal differentiation.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.095
Abstract: The βγ subunit of heterotrimeric G proteins, a key molecule in the G protein-coupled receptors (GPCRs) signaling pathway, has been shown to be an important factor in the modulation of the microtubule cytoskeleton. Gβγ has… read more here.
Keywords: subunit heterotrimeric; heterotrimeric proteins; interacts actin; actin filaments ... See more keywords
Unidirectional cooperative binding of fimbrin actin-binding domain 2 to actin filament.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.139
Abstract: Fimbrin forms bundles of parallel actin filaments in filopodia, but it remains unclear how fimbrin forms well-ordered bundles. To address this issue, we focused on the cooperative interaction between the actin-binding domain of fimbrin and… read more here.
Keywords: binding domain; actin; actin binding; fimbrin ... See more keywords
Tropomyosins Regulate the Severing Activity of Gelsolin in Isoform-Dependent and Independent Manners
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.11.3812
Abstract: The actin cytoskeleton fulfills numerous key cellular functions, which are tightly regulated in activity, localization, and temporal patterning by actin binding proteins. Tropomyosins and gelsolin are two such filament-regulating proteins. Here, we investigate how the… read more here.
Keywords: activity gelsolin; tropomyosin isoforms; gelsolin; actin filaments ... See more keywords