Actin isoform-specific interactions revealed by Vibrio VopV actin-binding repeats.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2523856122
Abstract: Despite an evolutionary separation of over 300 Mya, there are no amino acid substitutions in certain actin isoforms from reptiles to mammals. What divergence that does exist between different actin isoforms is primarily tissue-specific, rather… read more here.
Keywords: actin isoforms; specific interactions; actin binding; isoform specific ... See more keywords
Unique and redundant functions of cytoplasmic actins and nonmuscle myosin II isoforms at epithelial junctions
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14808
Abstract: The integrity and functions of epithelial barriers depend on the formation of adherens junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their association with the cortical cytoskeleton composed of… read more here.
Keywords: actin isoforms; redundant functions; myosin; unique redundant ... See more keywords
Biological Role of Actin Isoforms in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297919060014
Abstract: Actin plays an important role in cellular adhesion, muscle and non-muscle contractility, migration, polarization, mitosis, and meiosis. Investigation of specific mechanisms underlying these processes is essential not only for fundamental research but also for clinical… read more here.
Keywords: actin isoforms; actin; biological role; role actin ... See more keywords
Pick-ya actin – a method to purify actin isoforms with bespoke key post-translational modifications
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.241406
Abstract: ABSTRACT Actin is one of the most abundant eukaryotic cytoskeletal polymer-forming proteins, which, in the filamentous form, regulates a number of physiological processes, ranging from cell division and migration to development and tissue function. Actins… read more here.
Keywords: actin; post translational; method; actin isoforms ... See more keywords
Colocalization Analysis of Cytoplasmic Actin Isoforms Distribution in Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123194
Abstract: Actin cytoskeleton is an essential component of living cells and plays a decisive role in many cellular processes. In mammals, β- and γ-actin are cytoplasmic actin isoforms in non-muscle cells. Despite minor differences in the… read more here.
Keywords: actin isoforms; cell; colocalization; endothelial cells ... See more keywords
Structural insights into actin isoforms
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DOI: 10.7554/elife.82015
Abstract: Actin isoforms organize into distinct networks that are essential for the normal function of eukaryotic cells. Despite a high level of sequence and structure conservation, subtle differences in their design principles determine the interaction with… read more here.
Keywords: actin isoforms; structural insights; actin; actin actin ... See more keywords