The actin nucleator Cobl organises the terminal web of enterocytes
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DOI: 10.1038/s41598-020-66111-9
Abstract: Brush borders of intestinal epithelial cells are mandatory for nutrient uptake. Yet, which actin nucleators are crucial for forming the F-actin bundles supporting microvilli and the actin filaments of the terminal web, in which microvilli… read more here.
Keywords: cobl organises; actin nucleator; terminal web; nucleator cobl ... See more keywords
Phase separation of an actin nucleator by junctional microtubules regulates epithelial function
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DOI: 10.1126/sciadv.adf6358
Abstract: Liquid-liquid phase separation (LLPS) is involved in various dynamic biological phenomena. In epithelial cells, dynamic regulation of junctional actin filaments tethered to the apical junctional complex (AJC) is critical for maintaining internal homeostasis against external… read more here.
Keywords: phase separation; cobl; actin nucleator; actin ... See more keywords
Poststroke dendritic arbor regrowth requires the actin nucleator Cobl
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DOI: 10.1371/journal.pbio.3001399
Abstract: Ischemic stroke is a major cause of death and long-term disability. We demonstrate that middle cerebral artery occlusion (MCAO) in mice leads to a strong decline in dendritic arborization of penumbral neurons. These defects were… read more here.
Keywords: actin nucleator; nucleator cobl; cobl; poststroke dendritic ... See more keywords
The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling
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DOI: 10.1371/journal.ppat.1010277
Abstract: Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by… read more here.
Keywords: spir; actin nucleator; factor; immune signalling ... See more keywords