Reversible Deformation of Artificial Cell Colonies Triggered by Actin Polymerization for Muscle Behavior Mimicry
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202204039
Abstract: The use of artificial cells to mimic living tissues is beneficial for understanding the mechanism of interaction among cells. Artificial cells hold immense potential in the field of tissue engineering. Self‐powered artificial cells capable of… read more here.
Keywords: deformation; reversible deformation; artificial cells; muscle ... See more keywords
Computational simulation of formin‐mediated actin polymerization predicts homologue‐dependent mechanosensitivity
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21344
Abstract: Many actin structures are nucleated and assembled by the barbed‐end tracking polymerase formin family, including filopodia, focal adhesions, the cytokinetic ring and cell cortex. These structures respond to forces in distinct ways. Formins typically have… read more here.
Keywords: formin mediated; polymerization; barbed end; actin polymerization ... See more keywords
Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30769
Abstract: This study provides comprehensive mechanistic evidence for the role of clusterin, a stress‐response secretory chaperone protein, in the modulation of intraocular pressure (IOP) by regulating the trabecular meshwork (TM) actin cytoskeleton and the extracellular matrix… read more here.
Keywords: clusterin; actin polymerization; regulation; protein ... See more keywords
Truncation of CXCL8 to CXCL8(9‐77) enhances actin polymerization and in vivo migration of neutrophils
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ab0220-470r
Abstract: CXCL8 is the principal human neutrophil‐attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil‐chemotactic and neutrophil‐activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein‐coupled receptors (GPCRs) CXCR1… read more here.
Keywords: truncation; cxcl8 cxcl8; actin polymerization; nh2 terminal ... See more keywords
Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.012
Abstract: Aggregation of IgE bound to the high-affinity IgE receptor (FcεRI) by a multivalent antigen induces mast cell activation, while disaggregation of aggregated FcεRI by monomer hapten immediately terminates degranulation mediated by dephosphorylation of Syk and… read more here.
Keywords: polymerization; mast cells; actin polymerization; cofilin ... See more keywords
Biphasic Effect of Profilin Impacts the Formin mDia1 Force-Sensing Mechanism in Actin Polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.06.012
Abstract: Formins are force-sensing proteins that regulate actin polymerization dynamics. Here, we applied stretching tension to individual actin filaments under the regulation of formin mDia1 to investigate the mechanical responses in actin polymerization dynamics. We found… read more here.
Keywords: profilin; actin; actin polymerization; effect ... See more keywords
Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.02.058
Abstract: Mitochondrial damage (MtD) represents a dramatic change in cellular homeostasis, necessitating metabolic changes and stimulating mitophagy. One rapid response to MtD is a rapid peri-mitochondrial actin polymerization termed ADA (acute damage-induced actin). The activation mechanism… read more here.
Keywords: mitochondrial depolarization; shape changes; depolarization; actin polymerization ... See more keywords
mDia1 senses both force and torque during F-actin filament polymerization
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01745-4
Abstract: Formins, an important family of force-bearing actin-polymerizing factors, function as homodimers that bind with the barbed end of actin filaments through a ring-like structure assembled from dimerized FH2 domains. It has been hypothesized that force… read more here.
Keywords: actin; actin polymerization; force; actin filament ... See more keywords
The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08950-7
Abstract: Macrophage interactions with other cells, either locally or at distances, are imperative in both normal and pathological conditions. While soluble means of communication can transmit signals between different cells, it does not account for all… read more here.
Keywords: tnt formation; biogenesis; macrophage; actin polymerization ... See more keywords
Actin polymerization regulates recruitment of Nck to CD3ε upon T‐cell receptor triggering
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13146
Abstract: Following T‐cell antigen receptor (TCR) engagement, rearrangement of the actin cytoskeleton supports intracellular signal transduction and T‐cell activation. The non‐catalytic region of the tyrosine kinase (Nck) molecule is an adapter protein implicated in TCR‐induced actin… read more here.
Keywords: polymerization; actin polymerization; cell; recruitment nck ... See more keywords
Baculovirus AC102 Is a Nucleocapsid Protein That Is Crucial for Nuclear Actin Polymerization and Nucleocapsid Morphogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00111-18
Abstract: ABSTRACT The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the type species of alphabaculoviruses, is an enveloped DNA virus that infects lepidopteran insects and is commonly known as a vector for protein expression and cell transduction.… read more here.
Keywords: protein; actin; nucleocapsid morphogenesis; infection ... See more keywords