Reversible Deformation of Artificial Cell Colonies Triggered by Actin Polymerization for Muscle Behavior Mimicry
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202204039
Abstract: The use of artificial cells to mimic living tissues is beneficial for understanding the mechanism of interaction among cells. Artificial cells hold immense potential in the field of tissue engineering. Self‐powered artificial cells capable of… read more here.
Keywords: deformation; reversible deformation; artificial cells; muscle ... See more keywords
Computational simulation of formin‐mediated actin polymerization predicts homologue‐dependent mechanosensitivity
Sign Up to like & getrecommendations! Published in 2017 at "Cytoskeleton"
DOI: 10.1002/cm.21344
Abstract: Many actin structures are nucleated and assembled by the barbed‐end tracking polymerase formin family, including filopodia, focal adhesions, the cytokinetic ring and cell cortex. These structures respond to forces in distinct ways. Formins typically have… read more here.
Keywords: formin mediated; polymerization; barbed end; actin polymerization ... See more keywords
Characterization of open chromatin sensitive to actin polymerization and identification of core‐binding factor subunit beta as mechanosensitive nucleocytoplasmic shuttling protein
Sign Up to like & getrecommendations! Published in 2024 at "Cytoskeleton"
DOI: 10.1002/cm.21925
Abstract: Mechanotransduction leads to a variety of biological responses including gene expression, changes in cell shape, migration, tissue development, and immune responses. Dysregulation of mechanotransduction is implicated in the progression of various diseases such as cardiovascular… read more here.
Keywords: mechanosensitive nucleocytoplasmic; open chromatin; nucleocytoplasmic shuttling; core binding ... See more keywords
Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30769
Abstract: This study provides comprehensive mechanistic evidence for the role of clusterin, a stress‐response secretory chaperone protein, in the modulation of intraocular pressure (IOP) by regulating the trabecular meshwork (TM) actin cytoskeleton and the extracellular matrix… read more here.
Keywords: clusterin; actin polymerization; regulation; protein ... See more keywords
Truncation of CXCL8 to CXCL8(9‐77) enhances actin polymerization and in vivo migration of neutrophils
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ab0220-470r
Abstract: CXCL8 is the principal human neutrophil‐attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil‐chemotactic and neutrophil‐activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein‐coupled receptors (GPCRs) CXCR1… read more here.
Keywords: truncation; cxcl8 cxcl8; actin polymerization; nh2 terminal ... See more keywords
Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.012
Abstract: Aggregation of IgE bound to the high-affinity IgE receptor (FcεRI) by a multivalent antigen induces mast cell activation, while disaggregation of aggregated FcεRI by monomer hapten immediately terminates degranulation mediated by dephosphorylation of Syk and… read more here.
Keywords: polymerization; mast cells; actin polymerization; cofilin ... See more keywords
Biphasic Effect of Profilin Impacts the Formin mDia1 Force-Sensing Mechanism in Actin Polymerization.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.06.012
Abstract: Formins are force-sensing proteins that regulate actin polymerization dynamics. Here, we applied stretching tension to individual actin filaments under the regulation of formin mDia1 to investigate the mechanical responses in actin polymerization dynamics. We found… read more here.
Keywords: profilin; actin; actin polymerization; effect ... See more keywords
Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.02.058
Abstract: Mitochondrial damage (MtD) represents a dramatic change in cellular homeostasis, necessitating metabolic changes and stimulating mitophagy. One rapid response to MtD is a rapid peri-mitochondrial actin polymerization termed ADA (acute damage-induced actin). The activation mechanism… read more here.
Keywords: mitochondrial depolarization; shape changes; depolarization; actin polymerization ... See more keywords
Treponema pallidum Protein TpF1 Inhibits Migration by Impairing Actin Polymerization via Toll-Like Receptor 4/PI3K/AKT in Microglia.
Sign Up to like & getrecommendations! Published in 2025 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.4c00868
Abstract: Treponema pallidum induces a host immune response during central nervous system (CNS) invasion, prompting microglia to migrate to the site of injury, where they release effector molecules or phagocytose pathogens. However, the role of impaired… read more here.
Keywords: migration; actin polymerization; pallidum; pi3k akt ... See more keywords
mDia1 senses both force and torque during F-actin filament polymerization
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01745-4
Abstract: Formins, an important family of force-bearing actin-polymerizing factors, function as homodimers that bind with the barbed end of actin filaments through a ring-like structure assembled from dimerized FH2 domains. It has been hypothesized that force… read more here.
Keywords: actin; actin polymerization; force; actin filament ... See more keywords
The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08950-7
Abstract: Macrophage interactions with other cells, either locally or at distances, are imperative in both normal and pathological conditions. While soluble means of communication can transmit signals between different cells, it does not account for all… read more here.
Keywords: tnt formation; biogenesis; macrophage; actin polymerization ... See more keywords