The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.05.009
Abstract: The initial binding of tropomyosin onto actin filaments and then its polymerization into continuous cables on the filament surface must be precisely tuned to overall thin-filament structure, function, and performance. Low-affinity interaction of tropomyosin with… read more here.
Keywords: effect tropomyosin; tropomyosin; tropomyosin binding; actin tropomyosin ... See more keywords
Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton
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DOI: 10.1016/j.cub.2018.05.053
Abstract: Tropomyosin proteins form stable coiled-coil dimers that polymerize along the α-helical groove of actin filaments [1]. The actin cytoskeleton consists of both co-polymers of actin and tropomyosin and polymers of tropomyosin-free actin [2]. The fundamental… read more here.
Keywords: actin cytoskeleton; actin; tropomyosin; actin tropomyosin ... See more keywords
cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory Research"
DOI: 10.1186/s12931-018-0903-z
Abstract: BackgroundThe nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact molecular mechanism remains undefined.MethodsBiotin-cGMP pull-down assay was performed to search… read more here.
Keywords: tropomyosin myosin; tropomyosin; cgmp; actin tropomyosin ... See more keywords
Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice
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DOI: 10.1242/jcs.212654
Abstract: ABSTRACT Many actin filaments in animal cells are co-polymers of actin and tropomyosin. In many cases, non-muscle myosin II associates with these co-polymers to establish a contractile network. However, the temporal relationship of these three… read more here.
Keywords: myosin; tropomyosin; actin tropomyosin; assembly actin ... See more keywords