SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.101
Abstract: SH2 domain-containing inositol 5'-phosphatase (SHIP) has critical functions in regulating signal transduction. In additional to its lipid phosphatase activity, SHIP engages in multiple protein-protein interactions, which can serve to localize either SHIP or its binding… read more here.
Keywords: ship interacts; adaptor protein; interacts adaptor; ship ... See more keywords
Modeling cell protrusion predicts how Myosin II and actin turnover affect adhesion-based signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.11.2889
Abstract: Orchestration of cell migration is essential for development, tissue regeneration, and the immune response. This dynamic process integrates adhesion, signaling, and cytoskeletal subprocesses across spatial and temporal scales. In mesenchymal cells, adhesion complexes bound to… read more here.
Keywords: actin turnover; adhesion based; protrusion; cell ... See more keywords
Actin Turnover in Lamellipodial Fragments
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.08.066
Abstract: Actin turnover is the central driving force underlying lamellipodial motility. The molecular components involved are largely known, and their properties have been studied extensively in vitro. However, a comprehensive picture of actin turnover in vivo is still… read more here.
Keywords: network; actin; diffusible actin; turnover lamellipodial ... See more keywords
Myosin-dependent actin stabilization as revealed by single-molecule imaging of actin turnover
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-01-0061
Abstract: How mechanical stress applied to the actin network modifies actin turnover has attracted considerable attention. Actomyosin exerts the major force on the actin network, which has been implicated in actin stability regulation. However, direct monitoring… read more here.
Keywords: actin; actin network; actin turnover; single molecule ... See more keywords
Activation of actin-depolymerizing factor by CDPK16-mediated phosphorylation promotes actin turnover in Arabidopsis pollen tubes
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002073
Abstract: As the stimulus-responsive mediator of actin dynamics, actin-depolymerizing factor (ADF)/cofilin is subject to tight regulation. It is well known that kinase-mediated phosphorylation inactivates ADF/cofilin. Here, however, we found that the activity of Arabidopsis ADF7 is… read more here.
Keywords: mediated phosphorylation; cdpk16 mediated; actin turnover; phosphorylation ... See more keywords