New Insight Into the Mechanisms of Fast-Acting Antidepressants: What We Learn From Scopolamine
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.11.001
Abstract: For a depressed patient, a single day without symptom improvement means yet another day of suffering. The currently available antidepressants require weeks or months to achieve appreciable symptom remission and remain ineffective in a large… read more here.
Keywords: acting antidepressants; new insight; fast acting; rapid antidepressant ... See more keywords
A wake-up call: Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2021.102140
Abstract: Depression is frequently associated with sleep problems, and clinical improvement often coincides with the normalization of sleep architecture and realignment of circadian rhythm. The effectiveness of treatments targeting sleep in depressed patients, such as sleep… read more here.
Keywords: wake call; acting antidepressants; rapid acting; physiology ... See more keywords
Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation.
Sign Up to like & getrecommendations! Published in 2021 at "Nature neuroscience"
DOI: 10.1038/s41593-021-00868-8
Abstract: The rapidly acting antidepressants ketamine and scopolamine exert behavioral effects that can last from several days to more than a week in some patients. The molecular mechanisms underlying the maintenance of these antidepressant effects are… read more here.
Keywords: ketamine scopolamine; rapidly acting; acting antidepressants; mecp2 phosphorylation ... See more keywords
Rapid-Acting Antidepressants.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612824666180730104707
Abstract: BACKGROUND Conventional antidepressants are thought to produce their impact on clinical symptoms by increasing the central availability of biogenic amine neurotransmitters (the monoamine hypothesis of depression). These drugs continue to be the primary medicines used… read more here.
Keywords: acting antidepressants; rapid acting;