Reduction in liver transplant wait‐listing in the era of direct‐acting antiviral therapy
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28923
Abstract: Direct‐acting antiviral (DAA) therapy, recently approved for patients with decompensated cirrhosis (DC) secondary to hepatitis C virus (HCV), is associated with improved hepatic function. We analyzed trends in liver transplant (LT) wait‐listing (WL) to explore… read more here.
Keywords: era; daa; direct acting; acting antiviral ... See more keywords
Machine learning algorithms for predicting direct‐acting antiviral treatment failure in chronic hepatitis C: An HCV‐TARGET analysis
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32347
Abstract: We aimed to develop and validate machine learning algorithms to predict direct‐acting antiviral (DAA) treatment failure among patients with HCV infection. read more here.
Keywords: learning algorithms; machine learning; treatment failure; direct acting ... See more keywords
Amino acid substitutions in the hepatitis C virus core region predict hepatocarcinogenesis following eradication of HCV RNA by all‐oral direct‐acting antiviral regimens
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25047
Abstract: Impact of substitution of aa70 in the core region (Core aa70) in HCV genotype 1b (HCV‐1b) on hepatocarcinogenesis following eradication of HCV RNA by direct‐acting antiviral therapy is not clear. In a retrospective study, 533… read more here.
Keywords: hcv rna; direct acting; acting antiviral; hepatocarcinogenesis ... See more keywords
The effects of direct‐acting antiviral agents on the frequency of myeloid‐derived suppressor cells and natural killer cells in patients with chronic hepatitis C
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25302
Abstract: Currently, hepatitis C antiviral therapy is entering a new era with the use of direct‐acting antiviral (DAA) agents. However, the precise immunological influences of DAA therapy in patients with chronic hepatitis C (CHC) are insufficiently… read more here.
Keywords: hepatitis; frequency; direct acting; acting antiviral ... See more keywords
Liver and Spleen Stiffness Surveillance Through Elastography During and After Direct‐Acting Antiviral Therapy in Patients With Chronic Hepatitis C
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DOI: 10.1002/jum.15806
Abstract: Direct‐acting antiviral agents achieve a high cure rate, resulting in early hepatic necroinflammatory resolution and sustained fibrosis regression. This study aimed to obtain longitudinal, concurrent within‐subject measurements of liver stiffness (LS) and spleen stiffness (SS)… read more here.
Keywords: spleen stiffness; liver spleen; direct acting; acting antiviral ... See more keywords
Management of HCV-related decompensated cirrhosis with direct-acting antiviral agents: who should be treated?
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology International"
DOI: 10.1007/s12072-019-09933-8
Abstract: BackgroundMedical treatment of decompensated cirrhosis due to hepatitis C virus (HCV) remains a clinical challenge even in the era of direct-acting antiviral drugs (DAAs). We evaluated the efficacy and safety of DAAs in the management… read more here.
Keywords: cirrhosis; direct acting; acting antiviral; decompensated cirrhosis ... See more keywords
Changing Urban-Rural Disparities in the Utilization of Direct-Acting Antiviral Agents for Hepatitis C in U.S. Medicare Patients, 2014-2017.
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DOI: 10.1016/j.amepre.2020.08.031
Abstract: INTRODUCTION The advent of direct-acting antiviral agents for treating hepatitis C virus infection has made hepatitis C virus elimination possible. Rural patients with hepatitis C virus infection may be less likely to access direct-acting antiviral… read more here.
Keywords: direct acting; urban rural; acting antiviral; antiviral agents ... See more keywords
'REAL-LIFE' EXPERIENCE WITH DIRECT-ACTING ANTIVIRAL AGENTS FOR HCV AFTER KIDNEY TRANSPLANT.
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DOI: 10.1016/j.aohep.2021.100337
Abstract: INTRODUCTIONS AND OBJECTIVES The introduction of direct-acting antiviral agents promises to change dramatically the management of hepatitis C in kidney transplant recipients, a patient group where the treatment of hepatitis C was historically challenging. The… read more here.
Keywords: kidney transplant; direct acting; acting antiviral; antiviral agents ... See more keywords
Hepatitis C virus direct-acting antiviral nonadherence: Relationship to sustained virologic response and identification of at-risk patients.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Pharmacists Association : JAPhA"
DOI: 10.1016/j.japh.2018.10.020
Abstract: OBJECTIVES There is a dearth of literature on effects of nonadherence to hepatitis C virus (HCV) direct-acting antiviral (DAA) regimens; thus, the objective of our study was to assess the impact of adherence on sustained… read more here.
Keywords: sustained virologic; direct acting; acting antiviral; hepatitis virus ... See more keywords
Three cases of incident lichen planus after direct-acting antiviral treatment for hepatitis C
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DOI: 10.1016/j.jdcr.2018.10.004
Abstract: DAA: direct-acting antiviral HCV: hepatitis C virus LP: lichen planus SVR: sustained viral response UCSF: University of California, San Francisco H epatitis C virus (HCV) infection is associated with many extrahepatic manifestations, including skin diseases… read more here.
Keywords: treatment; daa; hcv; direct acting ... See more keywords
Patient-reported symptoms during and after direct acting antiviral therapies for chronic hepatitis C: The PROP UP Study.
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DOI: 10.1016/j.jhep.2019.04.016
Abstract: BACKGROUND & AIMS A comprehensive analysis of changes in symptoms and functioning during and after direct acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) has not been conducted for patients treated in real-world… read more here.
Keywords: treatment; direct acting; acting antiviral; chronic hepatitis ... See more keywords