Hepatocellular carcinoma after a sustained virological response by direct‐acting antivirals harbors TP53 inactivation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4571
Abstract: The genomic characteristics of hepatocellular carcinoma (HCC) after a sustained virological response (SVR) and its differences according to whether an SVR was achieved by treatment with direct‐acting antivirals (DAA) or interferon (IFN) are still not… read more here.
Keywords: sustained virological; hepatocellular carcinoma; acting antivirals; direct acting ... See more keywords
DIRECT‐ACTING ANTIVIRALS DURING OR AFTER IMMUNO‐CHEMOTHERAPY IN HEPATITIS C VIRUS‐ASSOCIATED DIFFUSE LARGE B‐CELL LYMPHOMAS
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2438_57
Abstract: vs 10.7%, p = 0.18) GVHD were also comparable as well as 2‐year GVHD free/relapse‐free survival (FB2: 44.4% vs 42.8%, p = 0.38). In multivariate analysis, there was a trend for worse outcome using FB3/FB4… read more here.
Keywords: chemotherapy hepatitis; direct acting; antivirals immuno; hepatitis virus ... See more keywords
Con: Treating hepatitis C virus With direct‐acting antivirals: Fear not the perceived threat of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Liver Transplantation"
DOI: 10.1002/lt.24959
Abstract: Direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection achieve sustained virological response (SVR) rates exceeding 90% in clinical trials and in the real-world setting. Although some studies have suggested an increased risk of hepatocellular… read more here.
Keywords: direct acting; hepatitis virus; hepatocellular carcinoma; acting antivirals ... See more keywords
Role of Liver Stiffness Measurement in Predicting HCC Occurrence in Direct-Acting Antivirals Setting: A Real-Life Experience
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05604-8
Abstract: PurposeThe aim of this study was to evaluate the relationship between the liver stiffness measurement and the risk of developing hepatocellular carcinoma (HCC) in HCV cirrhotic patients undergoing new direct-acting antivirals.MethodsFrom April 2015 to April… read more here.
Keywords: direct acting; liver stiffness; acting antivirals; stiffness measurement ... See more keywords
Local specialty pharmacy and specialty clinic collaboration assists access to hepatitis C direct-acting antivirals.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Pharmacists Association : JAPhA"
DOI: 10.1016/j.japh.2017.10.011
Abstract: OBJECTIVES To measure prescribed time to therapy (TtT) and sustained virologic response (SVR). Secondary objectives were to assess insurance appeals and copay assistance amount facilitated by a local specialty pharmacy (LSP). METHODS This descriptive, retrospective… read more here.
Keywords: specialty pharmacy; specialty; direct acting; pharmacy ... See more keywords
Chronic Hepatitis C Virus Infection After Kidney Transplantation With or Without Direct-Acting Antivirals in a Real-Life Setting: A French Multicenter Experience.
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2020.06.005
Abstract: PURPOSE Kidney transplant recipients (KTRs) are frequently infected with chronic hepatitis C virus (HCV), which can increase the risk of graft loss. Active HCV infections among KTRs are associated with shorter survival times. The emergence… read more here.
Keywords: hepatitis; group; direct acting; hepatitis virus ... See more keywords
Identification of HCV Resistant Variants against Direct Acting Antivirals in Plasma and Liver of Treatment Naïve Patients
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DOI: 10.1038/s41598-017-04931-y
Abstract: Current standard-of-care treatment of chronically infected hepatitis C virus (HCV) patients involves direct-acting antivirals (DAA). However, concerns exist regarding the emergence of drug -resistant variants and subsequent treatment failure. In this study, we investigate potential… read more here.
Keywords: plasma liver; treatment; treatment patients; direct acting ... See more keywords
Efficacy, Tolerability, and Compliance of Direct Acting Antivirals in Patients with HIV and Hepatitis C Coinfection: A Real-Life Experience.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0034
Abstract: Effective management of HIV and hepatitis C virus (HCV) coinfection warrants special emphasis on interactions between direct acting antivirals (DAAs) and antiretroviral therapy (ART) along with maintenance of treatment compliance. All HIV-HCV coinfected adult patients… read more here.
Keywords: real life; compliance; coinfection; acting antivirals ... See more keywords
Comparative Effectiveness of Direct-Acting Antivirals for Posttraumatic Stress Disorder in VA Patients with Hepatitis C Virus Infection.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of epidemiology"
DOI: 10.1093/aje/kwac104
Abstract: Our recent exploratory study indicated several direct-acting antivirals (DAAs), highly effective medications for hepatitis C virus (HCV) infection, were also associated with improvement in posttraumatic stress disorder (PTSD) among a national cohort of United States… read more here.
Keywords: sof; acting antivirals; hepatitis virus; gle pib ... See more keywords
Low Risk of Failing Direct-Acting Antivirals in People With Human Immunodeficiency Virus/Hepatitis C Virus From Sub-Saharan Africa or Southeastern Asia: A European Cross-Sectional Study
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac508
Abstract: Abstract Background Several studies have reported suboptimal efficacy of direct-acting antivirals (DAAs) to treat hepatitis C virus (HCV) subtypes endemic to sub-Saharan Africa (SSA) and Southeastern Asia (SEA). The extent of this issue in individuals… read more here.
Keywords: acting antivirals; hcv; hepatitis virus; direct acting ... See more keywords
Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug‐induced liver injury by direct acting antivirals
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology Research"
DOI: 10.1111/hepr.12893
Abstract: We prospectively screened patients treated with direct‐acting antivirals (DAA) in order to detect and analyze serum markers that are present prior to the development of drug‐induced liver injury (DILI). read more here.
Keywords: serum markers; liver injury; drug induced; direct acting ... See more keywords