Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01732
Abstract: Long-acting (LA) human immunodeficiency virus-1 (HIV-1) antiretroviral therapy characterized by a ≥1 month dosing interval offers significant advantages over daily oral therapy. However, the criteria for compounds that enter clinical development are high. Exceptional potency… read more here.
Keywords: inhibitors targeting; potent long; hiv; long acting ... See more keywords
Chalcones acting as inhibitors of cholinesterases, β-secretase and βamyloid aggregation and other targets for Alzheimer's disease: a critical review.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666201020151804
Abstract: BACKGROUND Alzheimer's disease (AD) is an irreversible and progressive neurodegeneration, with a multifactorial pathophysiology, including cholinergic deficit, amyloid plaques, neurofibrillary tangles, oxidative stress, and neurodegeneration. Despite the severity of the disease, the therapeutic arsenal is… read more here.
Keywords: acting inhibitors; alzheimer disease; chalcones acting; review ... See more keywords