Severe Hypoglycemia Risk With Long-Acting Insulin Analogs vs Neutral Protamine Hagedorn Insulin.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2020.9176
Abstract: Importance Previous studies have found that the risk of severe hypoglycemia does not differ between long-acting insulin analogs and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes. However, these studies did not… read more here.
Keywords: insulin; risk; long acting; hypoglycemia ... See more keywords
Pharmacokinetic Properties of Fast-acting Insulin Aspart Administered in Different Subcutaneous Injection Regions: Response to the commentary by Nuggehally R. Srinivas
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-017-0539-7
Abstract: We are grateful to Dr. Srinivas for his thorough review of our data. He points out potential differences in the pharmacodynamic effects of insulin preparations between healthy people and people with diabetes and discusses several… read more here.
Keywords: absorption; insulin; insulin aspart; acting insulin ... See more keywords
Analysis of Trends in Insulin Utilization and Spending Across Canada From 2010 to 2015.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of diabetes"
DOI: 10.1016/j.jcjd.2018.08.190
Abstract: OBJECTIVES To describe insulin utilization and spending across Canada and investigate how interprovincial variations in long-acting insulin uptake impact provincial spending. METHODS We conducted a cross-sectional time-series analysis of insulin products dispensed nationally from January… read more here.
Keywords: insulin; long acting; insulin utilization; spending ... See more keywords
Fast-Acting Insulin Aspart and the Need for New Mealtime Insulin Analogues in Adults With Type 1 and Type 2 Diabetes: A Canadian Perspective.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of diabetes"
DOI: 10.1016/j.jcjd.2019.01.004
Abstract: Limiting postprandial glucose (PPG) excursions is an important aspect of overall glycemic control. Rapid-acting insulin analogues (RAIAs) aim to mimic the physiologic action of endogenous insulin observed in individuals without diabetes and prevent excessive PPG… read more here.
Keywords: insulin; insulin analogues; type diabetes; insulin aspart ... See more keywords
Mass Casualty Incident Involving Rapid Acting Insulin
Sign Up to like & getrecommendations! Published in 2023 at "Prehospital Emergency Care"
DOI: 10.1080/10903127.2022.2162649
Abstract: Abstract We report on an unusual prehospital incident involving the inadvertent administration of short-acting insulin among a group of high school students. Sixteen students iatrogenically received 10 units of insulin lispro intradermally instead of tuberculin… read more here.
Keywords: casualty incident; incident; acting insulin; mass casualty ... See more keywords
Biosimilars and Novel Insulins.
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000001079
Abstract: BACKGROUND Insulin therapy is the mainstay of treatment for type 1 diabetes and may be necessary in type 2 diabetes. Current insulin analogues present a more physiological profile, are effective, and with less risk of… read more here.
Keywords: biosimilar insulins; insulin; insulin aspart; faster aspart ... See more keywords
Mealtime fast‐acting insulin aspart versus insulin aspart for controlling postprandial hyperglycaemia in people with insulin‐resistant Type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetic Medicine"
DOI: 10.1111/dme.13866
Abstract: This post hoc analysis explored whether mealtime fast‐acting insulin aspart treatment provided an advantage in postprandial plasma glucose (PPG) control vs. insulin aspart in people with Type 2 diabetes receiving high doses of bolus insulin. read more here.
Keywords: aspart; mealtime fast; insulin aspart; type diabetes ... See more keywords
Comparison of faster‐acting aspart with insulin aspart under conditions mimicking underestimation or missed meal boluses in type 1 diabetes using closed‐loop insulin delivery
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.1111/dom.14942
Abstract: Carbohydrate counting to quantify prandial insulin requirement remains a key aspect of type 1 diabetes self-management. This, however, remains challenging, leading to dysglycaemia and increased burden for many people with type 1 diabetes. Current hybrid… read more here.
Keywords: insulin aspart; faster acting; acting insulin; type diabetes ... See more keywords
Corrigendum to “Utilisation Trend of Long-Acting Insulin Analogues including Biosimilars across Europe: Findings and Implications”
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DOI: 10.1155/2023/9757348
Abstract: [This corrects the article DOI: 10.1155/2021/9996193.]. read more here.
Keywords: trend long; insulin analogues; utilisation trend; corrigendum utilisation ... See more keywords
The Non-Human Primate in Safety Assessment of a Bifunctional Long-Acting Insulin Analogue
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Toxicology"
DOI: 10.1177/10915818231156898
Abstract: Species selection plays a pivotal part during non-clinical safety assessment in drug development. If possible, use of non-human primates (NHPs) should be avoided due to ethical considerations. However, limiting factors as lack of pharmacologic activity… read more here.
Keywords: safety; lai pcsk9i; acting insulin; long acting ... See more keywords
Clinical effects, cardiovascular and renal outcomes associated with rapid-acting insulin analogs among individuals with type 2 diabetes: a nation-wide observational cohort study
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Diabetes and Endocrinology"
DOI: 10.1186/s40842-017-0043-2
Abstract: BackgroundRapid-acting insulin analogs (RAIs) have not been examined for long-term safety in randomized clinical trials. We performed a nationwide longitudinal cohort study among individuals with type 2 diabetes (T2DM) to address cardiovascular safety and mortality… read more here.
Keywords: individuals type; insulin analogs; among individuals; type diabetes ... See more keywords