Peripherally Acting μ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190017732263
Abstract: Opioid receptors are distributed throughout the central and peripheral nervous systems and on many nonneuronal cells. Therefore, opioid administration induces effects beyond analgesia. In the enteric nervous system (ENS), stimulation of µ-opioid receptors triggers several… read more here.
Keywords: opioid receptor; peripherally acting; opioid related; receptor antagonists ... See more keywords
Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030919
Abstract: Accumulated preclinical and clinical data show that peripheral restricted opioids provide pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a potent dual μ-/δ-opioid receptor (MOR/DOR) full agonist, and a weak,… read more here.
Keywords: acting opioid; opioid analgesic; opioid receptors; peripherally acting ... See more keywords
Long-Acting Opioid Analgesics for Acute Pain: Pharmacokinetic Evidence Reviewed
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary Sciences"
DOI: 10.3390/vetsci10060372
Abstract: Long-acting injectable (LAI) opioid formulations mitigate the harm profiles and management challenges associated with providing effective analgesia for animals. A single dose of a long-acting opioid analgesic can provide up to 72 h of clinically… read more here.
Keywords: acting opioid; opioid analgesics; pharmacokinetic evidence; evidence ... See more keywords