Mammalian Chemical Genomics towards Identifying Targets and Elucidating Modes‐of‐Action of Bioactive Compounds
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100561
Abstract: The step of identifying target molecules and elucidating the mode of action of bioactive compounds is a major bottleneck for drug discovery from phenotypic screening. Genetic screening for genes that affect drug sensitivity or phenotypes… read more here.
Keywords: chemical; action bioactive; target molecules; action ... See more keywords
Elucidating the modes of action for bioactive compounds in a cell-specific manner by large-scale chemically-induced transcriptomics
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40164
Abstract: The identification of the modes of action of bioactive compounds is a major challenge in chemical systems biology of diseases. Genome-wide expression profiling of transcriptional responses to compound treatment for human cell lines is a… read more here.
Keywords: large scale; modes action; bioactive compounds; action ... See more keywords