New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
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DOI: 10.1111/jdi.13925
Abstract: Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation… read more here.
Keywords: mechanism metformin; action mediated; mediated lysosomal; new mechanism ... See more keywords