Mechanisms of action of SGLT2 inhibitors and their beneficial effects on the cardiorenal axis.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2021-0399
Abstract: Large clinical studies conducted with sodium-glucose co-transporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes and heart failure with reduced ejection fraction have demonstrated their ability to achieve both cardiac and kidney benefits. Although… read more here.
Keywords: sglt2 inhibitors; action sglt2; cardiorenal axis; beneficial effects ... See more keywords
SGLT2 Inhibitors Produce Cardiorenal Benefits by Promoting Adaptive Cellular Reprogramming to Induce a State of Fasting Mimicry: A Paradigm Shift in Understanding Their Mechanism of Action
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes Care"
DOI: 10.2337/dci19-0074
Abstract: There is compelling evidence that sodium–glucose cotransporter 2 (SGLT2) inhibitors exert cardioprotective and renoprotective effects that are far greater than expected based on their effects on glycemia or glycosuria. In large-scale randomized controlled trials, SGLT2… read more here.
Keywords: state; sglt2 inhibitors; action sglt2; sglt2 ... See more keywords