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Published in 2019 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-019-0438-x
Abstract: Secondary findings (SF) differ from incidental findings as they are actively sought and systematically evaluated using a list of genes selected based on guidelines developed by professional societies in various jurisdictions. Despite some authors stating…
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Keywords:
findings considering;
genetics;
secondary findings;
actionability ... See more keywords
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Published in 2022 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-111021-032401
Abstract: Actionability is an important concept in medicine that does not have a well-accepted standard definition, nor is there a general consensus on how to establish it. Medical actionability is often conflated with clinical utility, a…
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Keywords:
actionability;
actionability genomic;
establishing medical;
genomic variants ... See more keywords
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Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs20-ps18-41
Abstract: Background: Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) of the breast typically present distinct clinicopathological characteristics and responsiveness to systemic therapy. In addition, breast cancer data from The Cancer Genome Atlas (TCGA) have…
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Keywords:
cancer;
breast cancer;
actionability;
genie consortium ... See more keywords
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Published in 2022 at "Orthopaedic Journal of Sports Medicine"
DOI: 10.1177/23259671221089977
Abstract: Background: Patients undergoing elective procedures often utilize online educational materials to familiarize themselves with the surgical procedure and expected postoperative recovery. While the Internet is easily accessible and ubiquitous today, the ability of patients to…
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Keywords:
actionability;
patients read;
surgery;
understandability actionability ... See more keywords
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Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14750
Abstract: e14750 Background: SIVHA01 was the first randomized precision medicine trial in patients (pts) with metastatic solid tumors comparing the efficacy of matched MTA outside their indications and conventional chemotherapy in pts with any kind of…
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Keywords:
according escat;
escat;
shiva01 according;
efficacy ... See more keywords
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Published in 2021 at "Oncotarget"
DOI: 10.18632/oncotarget.28021
Abstract: Introduction: Treatment options for biliary tract cancer (BTC) are very limited. It is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase (KB) and characterize BTCs immunologically for evaluating the actionability of…
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Keywords:
actionability;
actionable genes;
biliary tract;
candidate drugs ... See more keywords
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Published in 2018 at "Journal of Medical Internet Research"
DOI: 10.2196/jmir.8538
Abstract: Background Online health information is particularly important for cardiovascular disease (CVD) prevention, where lifestyle changes are recommended until risk becomes high enough to warrant pharmacological intervention. Online information is abundant, but the quality is often…
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Keywords:
risk;
risk calculators;
clinical validity;
cvd ... See more keywords
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Published in 2023 at "Current Oncology"
DOI: 10.3390/curroncol30020110
Abstract: Patient education materials (PEM)s were extracted from provincial cancer agencies to determine their organizational health literacy by evaluating the quality, actionability, and functional accessibility (e.g., readability and understandability) of their PEMs. PEMs from 10 provincial…
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Keywords:
actionability;
quality;
patient education;
education materials ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158506
Abstract: The implementation of high-throughput diagnostic sequencing has led to the generation of large amounts of mutational data, making their interpretation more complex and responsible for long delays. It has been important to prioritize certain analyses,…
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Keywords:
actionability;
objective evaluation;
involved myopathies;
actionability genes ... See more keywords