An Activatable and Covalent Tumor-Associated Antigen Capturer Enabling Systemic Injection In Vivo for Promoted Antitumor Immunity.
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DOI: 10.1021/jacs.5c09791
Abstract: Antigen-capturing nanomaterials hold great promise for cancer immunotherapy; however, the need for tumor localized administration and limited antigen-binding affinity remains the "Achilles heel" of this strategy. Herein, we present a tumor microenvironment (TME)-activatable nanoplatform, TDR848@FPB,… read more here.
Keywords: activatable covalent; enabling systemic; tumor associated; tumor ... See more keywords
Activatable covalent labeling probes: design, mechanism, and biological applications.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Society reviews"
DOI: 10.1039/d5cs00984g
Abstract: Stimuli-activatable covalent labeling probes have emerged as powerful tools for targeted biomolecule labeling, addressing the limitations of conventional covalent probes, such as off-target reactivity, limited spatiotemporal control, and low signal-to-background ratios. These probes remain inert… read more here.
Keywords: activatable covalent; labeling probes; covalent labeling; covalent ... See more keywords